Aldimines are aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
Aldimines are n class="Chemical">aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
Authors: Victor Galvão Mello; Heloisa Escudeiro; Ana Carolina Villas Bôas Weckwerth; Maria Izilda Andrade; Ana Elisa Fusaro; Eloise Brasil de Moraes; Luciana da Silva Ruiz; Ida Maria Foschiani Dias Baptista Journal: Mycopathologia Date: 2020-11-20 Impact factor: 2.574
Authors: Inaiá O Rocha; Yuri G Kappenberg; Wilian C Rosa; Clarissa P Frizzo; Nilo Zanatta; Marcos A P Martins; Isadora Tisoco; Bernardo A Iglesias; Helio G Bonacorso Journal: Beilstein J Org Chem Date: 2021-12-01 Impact factor: 2.883