(S)-[5-Methyl-3-(3-methyl-thio-phen-2-yl)-4,5-dihydro-isoxazol-5-yl]methanol.

In the title compound, C(10)H(13)NO(2)S, the thio-phene and isoxazoline rings are almost coplanar, the dihedral angle between their least-squares planes being 2.08 (1)°. The O-H atoms of the methyl hy-droxy group and the N atom of the isoxazole ring are orientated in the same direction to allow for the formation of inter-molecular O-H⋯N hydrogen bonds that lead to a supra-molecular chain along the a axis.

Related literature

For the synthesis, biological activity and mode of action of herbicides, see; Ryu et al. (2005 ▶); Hwang et al. (2005 ▶); Koo et al. (2007 ▶); Koo & Hwang (2008 ▶). For relevant reviews of herbicides, see; Boger et al. (2002 ▶); Bryant & Bite (2010 ▶).

Experimental

Crystal data

C10H13NO2S

M = 211.27

Orthorhombic,

a = 7.3672 (9) Å

b = 8.8534 (11) Å

c = 16.0632 (19) Å

V = 1047.7 (2) Å3

Z = 4

Mo Kα radiation

μ = 0.28 mm−1

T = 296 K

0.39 × 0.20 × 0.11 mm

Data collection

Bruker APEXII CCD diffractometer

Absorption correction: multi-scan (SADABS; Sheldrick, 1996 ▶) T min = 0.898, T max = 0.970

11038 measured reflections

2619 independent reflections

2096 reflections with I > 2σ(I)

R int = 0.025

Refinement

R[F 2 > 2σ(F 2)] = 0.047

wR(F 2) = 0.149

S = 1.08

2619 reflections

127 parameters

H-atom parameters constrained

Δρmax = 0.47 e Å−3

Δρmin = −0.36 e Å−3

Absolute structure: Flack (1983 ▶), 1087 Friedel pairs

Flack parameter: 0.02 (14)

Data collection: APEX2 (Bruker, 2009 ▶); cell refinement: SAINT (Bruker, 2009 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: XP in SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXL97.

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536811011639/tk2733sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536811011639/tk2733Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C10H13NO2S	F(000) = 448
Mr = 211.27	Dx = 1.339 Mg m−3
Orthorhombic, P212121	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 4205 reflections
a = 7.3672 (9) Å	θ = 2.5–26.1°
b = 8.8534 (11) Å	µ = 0.28 mm−1
c = 16.0632 (19) Å	T = 296 K
V = 1047.7 (2) Å3	Block, silver
Z = 4	0.39 × 0.20 × 0.11 mm

Bruker APEXII CCD diffractometer	2619 independent reflections
Radiation source: fine-focus sealed tube	2096 reflections with I > 2σ(I)
graphite	Rint = 0.025
φ and ω scans	θmax = 28.4°, θmin = 2.5°
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	h = −6→9
Tmin = 0.898, Tmax = 0.970	k = −11→11
11038 measured reflections	l = −21→21

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.047	H-atom parameters constrained
wR(F2) = 0.149	w = 1/[σ2(Fo2) + (0.086P)2 + 0.1644P] where P = (Fo2 + 2Fc2)/3
S = 1.08	(Δ/σ)max < 0.001
2619 reflections	Δρmax = 0.47 e Å−3
127 parameters	Δρmin = −0.36 e Å−3
0 restraints	Absolute structure: Flack (1983), 1087 Friedel pairs
Primary atom site location: structure-invariant direct methods	Flack parameter: 0.02 (14)

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
S1	−0.00757 (12)	0.90745 (7)	0.64150 (4)	0.0503 (2)
C2	−0.0074 (4)	0.8815 (3)	0.53306 (13)	0.0390 (4)
C3	−0.0070 (5)	0.7321 (3)	0.51314 (15)	0.0446 (5)
C4	−0.0075 (4)	0.6395 (3)	0.58618 (17)	0.0525 (6)
H4A	−0.0080	0.5345	0.5841	0.063*
C5	−0.0071 (5)	0.7169 (3)	0.65749 (17)	0.0568 (6)
H5	−0.0067	0.6721	0.7099	0.068*
C6	−0.0104 (4)	1.0139 (2)	0.47984 (12)	0.0368 (4)
N7	−0.0045 (4)	1.1462 (2)	0.51234 (11)	0.0448 (4)
O8	−0.0178 (4)	1.25711 (18)	0.45051 (10)	0.0490 (5)
C9	−0.0104 (4)	1.1857 (3)	0.36792 (13)	0.0405 (5)
C10	−0.0244 (4)	1.0174 (3)	0.38670 (13)	0.0423 (6)
H10A	−0.1394	0.9763	0.3679	0.051*
H10B	0.0740	0.9615	0.3610	0.051*
C11	0.1691 (4)	1.2299 (4)	0.3280 (2)	0.0630 (9)
H11A	0.1707	1.3369	0.3182	0.094*
H11B	0.1828	1.1774	0.2760	0.094*
H11C	0.2672	1.2033	0.3645	0.094*
C12	−0.1672 (4)	1.2500 (4)	0.31872 (17)	0.0452 (6)
H12A	−0.1627	1.3593	0.3219	0.054*
H12B	−0.1527	1.2219	0.2607	0.054*
O13	−0.3406 (2)	1.2007 (2)	0.34646 (11)	0.0489 (5)
H13	−0.3554	1.2261	0.3951	0.073*
C14	−0.0073 (5)	0.6707 (3)	0.42966 (17)	0.0507 (6)
H14A	−0.0080	0.7518	0.3900	0.076*
H14B	−0.1134	0.6093	0.4220	0.076*
H14C	0.0994	0.6101	0.4216	0.076*

	U11	U22	U33	U12	U13	U23
S1	0.0500 (4)	0.0629 (4)	0.0381 (3)	0.0022 (4)	−0.0002 (4)	0.0035 (2)
C2	0.0289 (10)	0.0484 (11)	0.0399 (9)	0.0021 (13)	−0.0002 (12)	0.0035 (8)
C3	0.0314 (11)	0.0483 (12)	0.0540 (13)	0.0039 (14)	0.0010 (14)	0.0021 (9)
C4	0.0406 (12)	0.0495 (13)	0.0673 (16)	0.0052 (15)	−0.0003 (17)	0.0198 (11)
C5	0.0458 (13)	0.0715 (17)	0.0529 (13)	0.0036 (18)	0.0057 (16)	0.0222 (12)
C6	0.0320 (10)	0.0401 (10)	0.0383 (10)	−0.0011 (13)	−0.0029 (12)	−0.0017 (8)
N7	0.0555 (12)	0.0430 (9)	0.0361 (8)	0.0010 (14)	−0.0045 (13)	0.0004 (7)
O8	0.0711 (14)	0.0379 (8)	0.0380 (8)	0.0026 (11)	−0.0086 (11)	−0.0009 (6)
C9	0.0412 (11)	0.0465 (11)	0.0340 (9)	−0.0041 (14)	−0.0004 (13)	0.0005 (8)
C10	0.0525 (15)	0.0389 (10)	0.0355 (9)	0.0021 (12)	−0.0024 (12)	−0.0035 (8)
C11	0.0416 (15)	0.079 (2)	0.069 (2)	−0.0069 (16)	0.0063 (15)	0.0075 (18)
C12	0.0408 (14)	0.0556 (15)	0.0391 (12)	0.0012 (13)	0.0003 (12)	0.0045 (11)
O13	0.0397 (9)	0.0606 (11)	0.0462 (10)	−0.0008 (9)	0.0025 (8)	−0.0063 (9)
C14	0.0455 (12)	0.0429 (12)	0.0637 (14)	0.0026 (15)	0.0004 (16)	0.0016 (10)

S1—C5	1.706 (3)	C9—C11	1.522 (4)
S1—C2	1.757 (2)	C9—C10	1.524 (3)
C2—C3	1.361 (3)	C10—H10A	0.9700
C2—C6	1.451 (3)	C10—H10B	0.9700
C3—C4	1.431 (3)	C11—H11A	0.9600
C3—C14	1.447 (3)	C11—H11B	0.9600
C4—C5	1.335 (4)	C11—H11C	0.9600
C4—H4A	0.9300	C12—O13	1.422 (3)
C5—H5	0.9300	C12—H12A	0.9700
C6—N7	1.283 (3)	C12—H12B	0.9700
C6—C10	1.500 (3)	O13—H13	0.8200
N7—O8	1.400 (2)	C14—H14A	0.9600
O8—C9	1.470 (3)	C14—H14B	0.9600
C9—C12	1.511 (4)	C14—H14C	0.9600
C5—S1—C2	91.14 (12)	C6—C10—H10A	111.3
C3—C2—C6	130.3 (2)	C9—C10—H10A	111.3
C3—C2—S1	111.12 (17)	C6—C10—H10B	111.3
C6—C2—S1	118.57 (17)	C9—C10—H10B	111.3
C2—C3—C4	111.4 (2)	H10A—C10—H10B	109.2
C2—C3—C14	125.7 (2)	C9—C11—H11A	109.5
C4—C3—C14	123.0 (2)	C9—C11—H11B	109.5
C5—C4—C3	114.1 (2)	H11A—C11—H11B	109.5
C5—C4—H4A	122.9	C9—C11—H11C	109.5
C3—C4—H4A	122.9	H11A—C11—H11C	109.5
C4—C5—S1	112.24 (19)	H11B—C11—H11C	109.5
C4—C5—H5	123.9	O13—C12—C9	114.0 (2)
S1—C5—H5	123.9	O13—C12—H12A	108.7
N7—C6—C2	119.83 (19)	C9—C12—H12A	108.7
N7—C6—C10	112.94 (18)	O13—C12—H12B	108.7
C2—C6—C10	127.22 (19)	C9—C12—H12B	108.7
C6—N7—O8	110.42 (17)	H12A—C12—H12B	107.6
N7—O8—C9	109.65 (16)	C12—O13—H13	109.5
O8—C9—C12	106.4 (2)	C3—C14—H14A	109.5
O8—C9—C11	107.6 (2)	C3—C14—H14B	109.5
C12—C9—C11	110.33 (19)	H14A—C14—H14B	109.5
O8—C9—C10	103.84 (16)	C3—C14—H14C	109.5
C12—C9—C10	114.8 (2)	H14A—C14—H14C	109.5
C11—C9—C10	113.2 (3)	H14B—C14—H14C	109.5
C6—C10—C9	102.27 (17)
C5—S1—C2—C3	0.0 (3)	C2—C6—N7—O8	−177.1 (3)
C5—S1—C2—C6	179.1 (2)	C10—C6—N7—O8	1.6 (4)
C6—C2—C3—C4	−178.8 (3)	C6—N7—O8—C9	−7.3 (3)
S1—C2—C3—C4	0.2 (4)	N7—O8—C9—C12	131.1 (2)
C6—C2—C3—C14	0.8 (6)	N7—O8—C9—C11	−110.7 (3)
S1—C2—C3—C14	179.8 (3)	N7—O8—C9—C10	9.5 (3)
C2—C3—C4—C5	−0.4 (4)	N7—C6—C10—C9	4.4 (4)
C14—C3—C4—C5	−180.0 (3)	C2—C6—C10—C9	−177.1 (3)
C3—C4—C5—S1	0.4 (4)	O8—C9—C10—C6	−8.0 (3)
C2—S1—C5—C4	−0.2 (3)	C12—C9—C10—C6	−123.7 (2)
C3—C2—C6—N7	−177.8 (4)	C11—C9—C10—C6	108.3 (3)
S1—C2—C6—N7	3.3 (4)	O8—C9—C12—O13	−70.1 (3)
C3—C2—C6—C10	3.7 (5)	C11—C9—C12—O13	173.5 (3)
S1—C2—C6—C10	−175.2 (3)	C10—C9—C12—O13	44.2 (3)

D—H···A	D—H	H···A	D···A	D—H···A
O13—H13···N7i	0.82	2.17	2.905 (3)	150

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O13—H13⋯N7i	0.82	2.17	2.905 (3)	150

Symmetry code: (i) .