Literature DB >> 2175180

Calcium ion-regulated phospholipase C activity in bovine rod outer segments.

I Panfoli1, A Morelli, I Pepe.   

Abstract

Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and accounted for 91 +/- 4 nmoles hydrolyzed/min/mg of protein. The results support the notion that in vivo the enzyme(s) is regulated so as to conform to the phototransduction events.

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Year:  1990        PMID： 2175180     DOI： 10.1016/s0006-291x(05)81054-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Identification of components of a phosphoinositide signaling pathway in retinal rod outer segments.

Authors:  Y W Peng; S G Rhee; W P Yu; Y K Ho; T Schoen; G J Chader; K W Yau
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

2.  Masses of inositol phosphates in resting and tetanically stimulated vertebrate skeletal muscles.

Authors:  G W Mayr; R Thieleczek
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

Review 3.  Lipid second messengers and related enzymes in vertebrate rod outer segments.

Authors:  Norma M Giusto; Susana J Pasquaré; Gabriela A Salvador; Mónica G Ilincheta de Boschero
Journal:  J Lipid Res       Date:  2009-10-14       Impact factor: 5.922

4.  Protein kinase C activity and light sensitivity of single amphibian rods.

Authors:  W Xiong; K Nakatani; B Ye; K Yau
Journal:  J Gen Physiol       Date:  1997-10       Impact factor: 4.086

5.  Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors.

Authors:  Susan Semple-Rowland; Irina Madorsky; Susan Bolch; Jonathan Berry; W Clay Smith
Journal:  PLoS One       Date:  2013-12-26       Impact factor: 3.240

Review 6.  Phosphoinositides in Retinal Function and Disease.

Authors:  Theodore G Wensel
Journal:  Cells       Date:  2020-04-02       Impact factor: 6.600
  6 in total

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