Literature DB >> 21751327

Synthesis, kinetic evaluation and cell-based analysis of C-alkylated isofagomines as chaperones of β-glucocerebrosidase.

Tara Hill1, Michael B Tropak, Don Mahuran, Stephen G Withers.   

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Year:  2011        PMID： 21751327     DOI： 10.1002/cbic.201100332

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  4 in total

1.  Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.

Authors:  Ethan D Goddard-Borger; Michael B Tropak; Sayuri Yonekawa; Christina Tysoe; Don J Mahuran; Stephen G Withers
Journal:  J Med Chem       Date:  2012-03-06       Impact factor: 7.446

2.  Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease.

Authors:  Francesca Clemente; Camilla Matassini; Andrea Goti; Amelia Morrone; Paolo Paoli; Francesca Cardona
Journal:  ACS Med Chem Lett       Date:  2019-02-08       Impact factor: 4.345

3.  Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.

Authors:  Rhianna J Rowland; Yurong Chen; Imogen Breen; Liang Wu; Wendy A Offen; Thomas J Beenakker; Qin Su; Adrianus M C H van den Nieuwendijk; Johannes M F G Aerts; Marta Artola; Herman S Overkleeft; Gideon J Davies
Journal:  Chemistry       Date:  2021-10-29       Impact factor: 5.020

4.  A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis.

Authors:  Rhianna J Rowland; Liang Wu; Feng Liu; Gideon J Davies
Journal:  Acta Crystallogr D Struct Biol       Date:  2020-05-29       Impact factor: 7.652
  4 in total

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