Literature DB >> 21751316

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments.

Cherng-Jyh Ke1, Tzu-Yuan Su, Hsin-Lung Chen, Hao-Li Liu, Wei-Lun Chiang, Po-Chun Chu, Younan Xia, Hsing-Wen Sung.   

Abstract

Prepared to self-destruct: when poly(D, L-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO(3) entered the endocytic organelles of a live cell, the NaHCO(3) in the aqueous core reacted with protons that infiltrated from the compartment to generate CO(2) gas. The evolution of CO(2) bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21751316     DOI： 10.1002/anie.201102852

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  16 in total

1.  Advances in Anticancer Protein Delivery Using Micro-/ Nanoparticles.

Authors:  Wujin Sun; Yue Lu; Zhen Gu
Journal:  Part Part Syst Charact       Date:  2014-10-16       Impact factor: 3.310

2.  Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.

Authors:  Yucai Wang; Min Suk Shim; Nathanael S Levinson; Hsing-Wen Sung; Younan Xia
Journal:  Adv Funct Mater       Date:  2014-07-16       Impact factor: 18.808

3.  Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

Authors:  Sheng Wang; Peng Huang; Xiaoyuan Chen
Journal:  Adv Mater       Date:  2016-06-03       Impact factor: 30.849

4.  Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.

Authors:  Ziming Yuan; Jingwen Zhao; Yigang Chen; Zhili Yang; Wenguo Cui; Qi Zheng
Journal:  Mediators Inflamm       Date:  2014-03-25       Impact factor: 4.711

5.  Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI.

Authors:  Ahmed Atef Ahmed Ali; Fei-Ting Hsu; Chia-Ling Hsieh; Chia-Yang Shiau; Chiao-Hsi Chiang; Zung-Hang Wei; Cheng-Yu Chen; Hsu-Shan Huang
Journal:  Sci Rep       Date:  2016-11-11       Impact factor: 4.379

6.  A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures.

Authors:  Dinggeng He; Xing He; Xue Yang; Hung-Wing Li
Journal:  Chem Sci       Date:  2017-01-19       Impact factor: 9.825

7.  Co-delivery of polyinosinic:polycytidylic acid and flagellin by poly(lactic-co-glycolic acid) MPs synergistically enhances immune response elicited by intranasally delivered hepatitis B surface antigen.

Authors:  Xiaojing Dai; Jintian He; Ruxia Zhang; Guanghao Wu; Fangfang Xiong; Baohua Zhao
Journal:  Int J Nanomedicine       Date:  2017-09-07

Review 8.  Hollow structures as drug carriers: Recognition, response, and release.

Authors:  Decai Zhao; Nailiang Yang; Lekai Xu; Jiang Du; Yang Yang; Dan Wang
Journal:  Nano Res       Date:  2021-07-08       Impact factor: 8.897

9.  A Targeted DNAzyme-Nanocomposite Probe Equipped with Built-in Zn(2+) Arsenal for Combined Treatment of Gene Regulation and Drug Delivery.

Authors:  Zhi-Mei He; Peng-Hui Zhang; Xin Li; Jian-Rong Zhang; Jun-Jie Zhu
Journal:  Sci Rep       Date:  2016-03-09       Impact factor: 4.379

10.  Sequential Delivery of Cyclopeptide RA-V and Doxorubicin for Combination Therapy on Resistant Tumor and In Situ Monitoring of Cytochrome c Release.

Authors:  Huachao Chen; Yurong Wang; Yongrong Yao; Shenglin Qiao; Hao Wang; Ninghua Tan
Journal:  Theranostics       Date:  2017-08-23       Impact factor: 11.556
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