BACKGROUND: Several studies have shown that predictors of asthma treatment outcomes differ depending on the definition of the outcome chosen. This provides evidence that different outcomes studied may reflect distinct aspects of asthma control. To assess predictors of asthma control, we need firm outcome phenotypes. The aim of this study was to investigate the association between measurements of current and long-term asthma control. METHODS: We included 527 children using inhaled corticosteroids participating in the Pharmacogenetics of Asthma medication in Children: Medication with ANti-inflammatory effects cohort. Current asthma control (previous week) was defined using the Asthma Control Questionnaire. Long-term asthma control was based on Global Initiative for Asthma guidelines. Not well-controlled asthma in a season was defined as ≥ 3 of the following items present in a season: (i) day-time or (ii) night-time symptoms, (iii) limitations in activities, and (iv) rescue medication use. Asthma control during (i) the previous season and (ii) the year preceding the pharmacy visit was used as long-term asthma control definitions. Current and long-term asthma control were compared to investigate agreement. RESULTS: Long-term uncontrolled asthma rates were highest in autumn and winter (50%) and lowest in summer (32%) (p < 0.05). Overall agreement between current and long-term asthma control was limited (66% for previous season and 68% for previous year). CONCLUSION: Congruence between current and long-term asthma control was limited. Furthermore, we showed significant seasonal differences. It is therefore important to calculate asthma control over a longer period of time, instead of using current asthma control as indicator.
BACKGROUND: Several studies have shown that predictors of asthma treatment outcomes differ depending on the definition of the outcome chosen. This provides evidence that different outcomes studied may reflect distinct aspects of asthma control. To assess predictors of asthma control, we need firm outcome phenotypes. The aim of this study was to investigate the association between measurements of current and long-term asthma control. METHODS: We included 527 children using inhaled corticosteroids participating in the Pharmacogenetics of Asthma medication in Children: Medication with ANti-inflammatory effects cohort. Current asthma control (previous week) was defined using the Asthma Control Questionnaire. Long-term asthma control was based on Global Initiative for Asthma guidelines. Not well-controlled asthma in a season was defined as ≥ 3 of the following items present in a season: (i) day-time or (ii) night-time symptoms, (iii) limitations in activities, and (iv) rescue medication use. Asthma control during (i) the previous season and (ii) the year preceding the pharmacy visit was used as long-term asthma control definitions. Current and long-term asthma control were compared to investigate agreement. RESULTS: Long-term uncontrolled asthma rates were highest in autumn and winter (50%) and lowest in summer (32%) (p < 0.05). Overall agreement between current and long-term asthma control was limited (66% for previous season and 68% for previous year). CONCLUSION: Congruence between current and long-term asthma control was limited. Furthermore, we showed significant seasonal differences. It is therefore important to calculate asthma control over a longer period of time, instead of using current asthma control as indicator.
Authors: Z Li; W L Leite; L A Thompson; H E Gross; E A Shenkman; B B Reeve; D A DeWalt; I-C Huang Journal: Clin Exp Allergy Date: 2016-10-21 Impact factor: 5.018
Authors: Pranav K Gandhi; Carolyn E Schwartz; Bryce B Reeve; Darren A DeWalt; Heather E Gross; I-Chan Huang Journal: Qual Life Res Date: 2016-04-09 Impact factor: 4.147
Authors: S J H Vijverberg; E S Koster; R Tavendale; M Leusink; L Koenderman; J A M Raaijmakers; D S Postma; G H Koppelman; S W Turner; S Mukhopadhyay; S M Tse; K G Tantisira; D B Hawcutt; B Francis; M Pirmohamed; M Pino-Yanes; C Eng; E G Burchard; C N A Palmer; A H Maitland-van der Zee Journal: Clin Exp Allergy Date: 2015-06 Impact factor: 5.018
Authors: Pranav K Gandhi; Kelly M Kenzik; Lindsay A Thompson; Darren A DeWalt; Dennis A Revicki; Elizabeth A Shenkman; I-Chan Huang Journal: Respir Res Date: 2013-02-23
Authors: Erwin C Vasbinder; Hettie M Janssens; Maureen P M H Rutten-van Mölken; Liset van Dijk; Brenda C M de Winter; Ruben C A de Groot; Arnold G Vulto; Patricia M L A van den Bemt Journal: BMC Med Inform Decis Mak Date: 2013-03-21 Impact factor: 2.796
Authors: Susanne J H Vijverberg; Leo Koenderman; Francine C van Erp; Cornelis K van der Ent; Dirkje S Postma; Paul Brinkman; Peter J Sterk; Jan A M Raaijmakers; Anke-Hilse Maitland-van der Zee Journal: BMC Pediatr Date: 2013-06-15 Impact factor: 2.125