BACKGROUND: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. METHODS: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes. RESULTS: The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/ lifestyles was significant for IL10-1082 (p = 0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p = 0.016) and atopy (p = 0.034), IL8 781 on atopic eczema (p = 0.0096), CD14 -550 on current rhinitis (p = 0.022), IFNgR1 -56 on atopic eczema(p = 0.038), and STAT6 2964 on current itchy rash (p = 0.037) and total serum IgE (p = 0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p = 0.003) and Russian (p = 0.01) children and overall (pooling the two populations together, p = 0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. CONCLUSIONS: Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations.
BACKGROUND: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. METHODS: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes. RESULTS: The genotype-phenotype relationships differed in Finnish and Russian Karelian children. The interaction between polymorphisms and the variable representing 'Western' and 'Eastern' environments/ lifestyles was significant for IL10-1082 (p = 0.0083) on current rhinitis, IL12b 6408 on current conjunctivitis (p = 0.016) and atopy (p = 0.034), IL8 781 on atopic eczema (p = 0.0096), CD14 -550 on current rhinitis (p = 0.022), IFNgR1 -56 on atopic eczema(p = 0.038), and STAT6 2964 on current itchy rash (p = 0.037) and total serum IgE (p = 0.042). In addition, the G allele of IL13 130 was associated with a lower level of total serum IgE in Finnish (p = 0.003) and Russian (p = 0.01) children and overall (pooling the two populations together, p = 0.00006). After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. CONCLUSIONS: Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations.
Authors: Sunita Sharma; Audrey Poon; Blanca E Himes; Jessica Lasky-Su; Joanne E Sordillo; Kathleen Belanger; Donald K Milton; Michael B Bracken; Elizabeth W Triche; Brian P Leaderer; Diane R Gold; Augusto A Litonjua Journal: Pediatr Allergy Immunol Date: 2011-12-23 Impact factor: 6.377
Authors: Mario G Ortiz-Martínez; Orquídea Frías-Belén; Sylvette Nazario-Jiménez; María López-Quintero; Rosa I Rodríguez-Cotto; Braulio D Jiménez-Vélez Journal: BMC Pulm Med Date: 2016-08-05 Impact factor: 3.317
Authors: Orsolya Lautner-Csorba; András Gézsi; Dániel J Erdélyi; Gábor Hullám; Péter Antal; Ágnes F Semsei; Nóra Kutszegi; Gábor Kovács; András Falus; Csaba Szalai Journal: PLoS One Date: 2013-08-05 Impact factor: 3.240
Authors: Guicheng Zhang; Siew-Kim Khoo; Mika J Mäkelä; Pierre Candelaria; Catherine M Hayden; Leena von Hertzen; Tiina Laatikainen; Erkki Vartiainen; Jack Goldblatt; Tari Haahtela; Peter N LeSouëf Journal: Allergy Asthma Immunol Res Date: 2014-03-20 Impact factor: 5.764