Literature DB >> 21749209

The Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial: study design.

Samer Arnous1, Abdul Mozid, Anthony Mathur.   

Abstract

The field of autologous stem/progenitor cell therapy for cardiovascular diseases has moved rapidly from bench to bedside. In particular, a small number of pilot studies have demonstrated the safety and efficacy of this treatment in dilated cardiomyopathy (DCM), but this has to be validated in large randomized trials. Here we introduce the Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial, which to our knowledge, is the first randomized, double-blind, placebo-controlled trial worldwide to investigate the role of granulocyte-colony stimulating factor and autologous bone marrow-derived stem/progenitor cells to improve cardiac function in patients with DCM.

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Year:  2011        PMID： 21749209     DOI： 10.2217/rme.11.29

Source DB:  PubMed          Journal:  Regen Med        ISSN： 1746-0751            Impact factor:   3.806


  5 in total

Review 1.  Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies.

Authors:  Hamayak Sisakian
Journal:  World J Cardiol       Date:  2014-06-26

2.  Stem cells and regenerative medicine in sport science.

Authors:  Claire E Stewart
Journal:  Emerg Top Life Sci       Date:  2021-10-29

3.  Does pretreatment of bone marrow mesenchymal stem cells with 5-azacytidine or double intravenous infusion improve their therapeutic potential for dilated cardiomyopathy?

Authors:  Sirui Yang; Jinhua Piao; Lianhua Jin; Yan Zhou
Journal:  Med Sci Monit Basic Res       Date:  2013-01-14

4.  Stem cell therapy for dilated cardiomyopathy.

Authors:  Rienzi Diaz-Navarro; Gerard Urrútia; John Gf Cleland; Daniel Poloni; Francisco Villagran; Roberto Acosta-Dighero; Shrikant I Bangdiwala; Gabriel Rada; Eva Madrid
Journal:  Cochrane Database Syst Rev       Date:  2021-07-21

5.  Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial.

Authors:  Stephen Hamshere; Samer Arnous; Tawfiq Choudhury; Fizzah Choudry; Abdul Mozid; Chia Yeo; Catherine Barrett; Natalie Saunders; Ankur Gulati; Charles Knight; Didier Locca; Ceri Davies; Martin R Cowie; Sanjay Prasad; Mahesh Parmar; Samir Agrawal; Daniel Jones; John Martin; William McKenna; Anthony Mathur
Journal:  Eur Heart J       Date:  2015-09-02       Impact factor: 29.983
  5 in total

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