BACKGROUND: Numerous reports suggest the application of platelet-rich plasma (PRP) during TKA may decrease postoperative bleeding. Because excessive bleeding can increase postoperative pain and inflammation, use of PRP also reportedly decreases the need for narcotics and increases speed of recovery after TKA. Because previous investigations of PRP and TKA reflect a weak level of medical evidence, we sought to confirm these findings. QUESTIONS/PURPOSES: We asked whether an intraoperative application of PRP gel to the deep wound reduced postoperative bleeding after TKA. METHODS: We retrospectively reviewed the charts of all 134 patients who received an intraoperative application of PRP during TKA from November 2009 to April 2010 and all 139 patients undergoing TKA who did not receive PRP between September 2009 to November 2009. Patients' charts were reviewed to identify detailed data, including hemoglobin level, ROM, postoperative narcotic use, and length of hospital stay. Blood loss was determined by the hemoglobin drop on postoperative Day 2. RESULTS: The blood loss between study groups was similar (3.6 g/dL [study] versus 3.8 g/dL [controls]). Differences in passive ROM (88° versus 88°), narcotic requirement (27 versus 32 morphine equivalent), and length of stay (2.4 versus 2.6 days) were also similar. CONCLUSION: We found no clinically important differences in patients who received an intraoperative application of PRP compared with patients who did not receive PRP and therefore could not confirm the findings of previous studies.
BACKGROUND: Numerous reports suggest the application of platelet-rich plasma (PRP) during TKA may decrease postoperative bleeding. Because excessive bleeding can increase postoperative pain and inflammation, use of PRP also reportedly decreases the need for narcotics and increases speed of recovery after TKA. Because previous investigations of PRP and TKA reflect a weak level of medical evidence, we sought to confirm these findings. QUESTIONS/PURPOSES: We asked whether an intraoperative application of PRP gel to the deep wound reduced postoperative bleeding after TKA. METHODS: We retrospectively reviewed the charts of all 134 patients who received an intraoperative application of PRP during TKA from November 2009 to April 2010 and all 139 patients undergoing TKA who did not receive PRP between September 2009 to November 2009. Patients' charts were reviewed to identify detailed data, including hemoglobin level, ROM, postoperative narcotic use, and length of hospital stay. Blood loss was determined by the hemoglobin drop on postoperative Day 2. RESULTS: The blood loss between study groups was similar (3.6 g/dL [study] versus 3.8 g/dL [controls]). Differences in passive ROM (88° versus 88°), narcotic requirement (27 versus 32 morphine equivalent), and length of stay (2.4 versus 2.6 days) were also similar. CONCLUSION: We found no clinically important differences in patients who received an intraoperative application of PRP compared with patients who did not receive PRP and therefore could not confirm the findings of previous studies.
Authors: G J Wang; D S Hungerford; C G Savory; A G Rosenberg; M A Mont; S G Burks; S L Mayers; W D Spotnitz Journal: J Bone Joint Surg Am Date: 2001-10 Impact factor: 5.284
Authors: Wieger G Horstmann; Robert Slappendel; Gijs G van Hellemondt; Ate W Wymenga; Nigel Jack; Peter A M Everts Journal: Knee Surg Sports Traumatol Arthrosc Date: 2010-07-18 Impact factor: 4.342
Authors: P A M Everts; R J J Devilee; C Brown Mahoney; M Eeftinck-Schattenkerk; H A M Box; J T A Knape; A van Zundert Journal: Acta Anaesthesiol Scand Date: 2006-05 Impact factor: 2.105
Authors: Taralyn M McCarrel; Nathan A Mall; Andrew S Lee; Brian J Cole; Davietta C Butty; Lisa A Fortier Journal: Sports Med Date: 2014-08 Impact factor: 11.136
Authors: Antonio Barile; Alice La Marra; Francesco Arrigoni; Silvia Mariani; Luigi Zugaro; Alessandra Splendiani; Ernesto Di Cesare; Alfonso Reginelli; Marcello Zappia; Luca Brunese; Ejona Duka; Giampaolo Carrafiello; Carlo Masciocchi Journal: Br J Radiol Date: 2016-07-07 Impact factor: 3.039