Literature DB >> 21748431

Eureka! Ets a target for fibrosis!

Andrew Leask1.   

Abstract

The oncogenic Ets family of transcription factors is now recognized to play a key role in fibroblasts as it controls the expression of a variety of pro-fibrotic genes, including the induction of CCN2 by transforming growth factor β. A recent report (Baran et al., Am J Respir Cell Mol Biol. 2011 May 11) shows that mice containing a version of ets2 that is incapable of being phosphorylated are resistant to bleomycin-induced lung fibrosis. This latter paper is the subject of this commentary.

Entities:  

Year:  2011        PMID： 21748431      PMCID： PMC3245763          DOI： 10.1007/s12079-011-0145-z

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  23 in total

1.  Synchronous activation of ERK and phosphatidylinositol 3-kinase pathways is required for collagen and extracellular matrix production in keloids.

Authors:  Ivor J Lim; Toan-Thang Phan; Ee-Kim Tan; Thi-Thanh T Nguyen; Evelyne Tran; Michael T Longaker; Colin Song; Seng-Teik Lee; Hung-The Huynh
Journal:  J Biol Chem       Date:  2003-08-07       Impact factor: 5.157

2.  c-ets-2 protooncogene has mitogenic and oncogenic activity.

Authors:  A Seth; D K Watson; D G Blair; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

3.  Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Authors:  Markella Ponticos; Alan M Holmes; Xu Shi-wen; Patricia Leoni; Korsa Khan; Vineeth S Rajkumar; Rachel K Hoyles; George Bou-Gharios; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask; Gisela E Lindahl
Journal:  Arthritis Rheum       Date:  2009-07

4.  Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program.

Authors:  Sashidhar S Nakerakanti; Bagrat Kapanadze; Masaomi Yamasaki; Margaret Markiewicz; Maria Trojanowska
Journal:  J Biol Chem       Date:  2006-07-06       Impact factor: 5.157

5.  Identification of ETS-1 target genes in human fibroblasts.

Authors:  Jens Claus Hahne; Ali Fuat Okuducu; Tanja Fuchs; Alexandra Florin; Nicolas Wernert
Journal:  Int J Oncol       Date:  2011-03-21       Impact factor: 5.650

6.  The avian and mammalian ets genes: molecular characterization, chromosome mapping, and implication in human leukemia.

Authors:  D K Watson; N Sacchi; M J McWilliams-Smith; S J O'Brien; T S Papas
Journal:  Anticancer Res       Date:  1986 Jul-Aug       Impact factor: 2.480

7.  CCN2 is required for bleomycin-induced skin fibrosis in mice.

Authors:  Shangxi Liu; Xu Shi-wen; David J Abraham; Andrew Leask
Journal:  Arthritis Rheum       Date:  2011-01

8.  Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

Authors:  Andrew Leask; Alan Holmes; Carol M Black; David J Abraham
Journal:  J Biol Chem       Date:  2003-02-05       Impact factor: 5.157

Review 9.  Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

Authors:  Aykut Uren; Jeffrey A Toretsky
Journal:  Future Oncol       Date:  2005-08       Impact factor: 3.404

10.  Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

Authors:  Shi-wen Xu; Sarah L Howat; Elisabetta A Renzoni; Alan Holmes; Jeremy D Pearson; Michael R Dashwood; George Bou-Gharios; Christopher P Denton; Roland M du Bois; Carol M Black; Andrew Leask; David J Abraham
Journal:  J Biol Chem       Date:  2004-03-23       Impact factor: 5.157
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  2 in total

1.  Getting out of a sticky situation: targeting the myofibroblast in scleroderma.

Authors:  Andrew Leask
Journal:  Open Rheumatol J       Date:  2012-06-15

2.  Novel blood-based microRNA biomarker panel for early diagnosis of chronic pancreatitis.

Authors:  Lei Xin; Jun Gao; Dan Wang; Jin-Huan Lin; Zhuan Liao; Jun-Tao Ji; Ting-Ting Du; Fei Jiang; Liang-Hao Hu; Zhao-Shen Li
Journal:  Sci Rep       Date:  2017-01-11       Impact factor: 4.379
  2 in total

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