Literature DB >> 21747899

Lactic acidosis expediting a diagnosis of acute lymphoblastic leukaemia.

Heather Young1, Salil Singh, Brigit Fiona Greystoke, Robert Paul Willert.   

Abstract

We report the finding of a low venous bicarbonate and lactic acidosis in a patient with mild pancytopenia which raised the suspicion of haematological malignancy and expedited the diagnosis of acute lymphoblastic leukaemia. This report highlights the value of testing for lactic acidosis when haematological malignancies are considered and reviews the metabolism of lactic acidosis.

Entities:  

Year:  2009        PMID： 21747899      PMCID： PMC3028298          DOI： 10.1136/bcr.02.2009.1601

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  6 in total

Review 1.  Type B lactic acidosis as a severe metabolic complication in lymphoma and leukemia: a case series from a single institution and literature review.

Authors:  Allison S Friedenberg; Douglas E Brandoff; Fred J Schiffman
Journal:  Medicine (Baltimore)       Date:  2007-07       Impact factor: 1.889

2.  Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.

Authors:  M Tiefenthaler; A Amberger; N Bacher; B L Hartmann; R Margreiter; R Kofler; G Konwalinka
Journal:  Br J Haematol       Date:  2001-09       Impact factor: 6.998

3.  Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature.

Authors:  E M Sillos; J L Shenep; G A Burghen; C H Pui; F G Behm; J T Sandlund
Journal:  Cancer       Date:  2001-11-01       Impact factor: 6.860

Review 4.  Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.

Authors:  S P Mathupala; A Rempel; P L Pedersen
Journal:  J Bioenerg Biomembr       Date:  1997-08       Impact factor: 2.945

5.  Lactic acidosis in a patient with acute leukemia.

Authors:  L Grossman; R Holloway; M D'Costa; D Roncari; A Lazarovits; M Baker; D Pantalony
Journal:  Clin Invest Med       Date:  1983       Impact factor: 0.825

6.  Definition of clinically relevant lactic acidosis in patients with internal diseases.

Authors:  D Luft; G Deichsel; R M Schmülling; W Stein; M Eggstein
Journal:  Am J Clin Pathol       Date:  1983-10       Impact factor: 2.493
  6 in total

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