Literature DB >> 21745474

Nuclear receptors: TH17 cell control from within.

L Klotz1, P Knolle.   

Abstract

IL-17 producing T helper (T(H)17) cells have recently been identified as a new subset involved in the pathogenesis of various autoimmune diseases. Exogenous factors promoting T(H)17 induction have been intensely characterized, whereas the T cell-intrinsic mechanisms influencing T(H)17 development are less established. The transcription factor RORγt, which belongs to the nuclear receptor superfamily, serves as master transcription factor essential for T(H)17 differentiation, whereas other members of the nuclear receptor family control T(H)17 differentiation and contribute to protection from T(H)17-mediated autoimmunity. In this review, we will highlight the most recent understandings about the regulatory function of nuclear receptors during T(H)17 cell differentiation.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21745474     DOI： 10.1016/j.febslet.2011.06.027

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.

Authors:  Monan Angela Zhang; Dorothy Rego; Marina Moshkova; Hania Kebir; Andrzej Chruscinski; Hoangkim Nguyen; Rainer Akkermann; Frank Z Stanczyk; Alexandre Prat; Lawrence Steinman; Shannon E Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-30       Impact factor: 11.205

Review 2.  The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases.

Authors:  Benjamin V Park; Fan Pan
Journal:  Cell Mol Immunol       Date:  2015-09       Impact factor: 11.530

3.  Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.

Authors:  Annie Bernier; Aurélie Cleret-Buhot; Yuwei Zhang; Jean-Philippe Goulet; Patricia Monteiro; Annie Gosselin; Sandrina DaFonseca; Vanessa Sue Wacleche; Mohammad-Ali Jenabian; Jean-Pierre Routy; Cécile Tremblay; Petronela Ancuta
Journal:  Retrovirology       Date:  2013-12-21       Impact factor: 4.602

4.  Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells.

Authors:  Dong Hyeok Kim; Hyun-Ju Ihn; Chaerin Moon; Sang-Seok Oh; Soojong Park; Suk Kim; Keun Woo Lee; Kwang Dong Kim
Journal:  Biomol Ther (Seoul)       Date:  2015-01-01       Impact factor: 4.634

5.  Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer.

Authors:  Junfeng Sun; Haowei Jia; Xingqi Bao; Yue Wu; Tianyu Zhu; Ruixin Li; Hongchao Zhao
Journal:  Cell Death Dis       Date:  2021-01-25       Impact factor: 8.469

Review 6.  Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier.

Authors:  Shanshan Chen; Ruonan He; Beihui He; Li Xu; Shuo Zhang
Journal:  J Immunol Res       Date:  2021-08-25       Impact factor: 4.818

7.  PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?

Authors:  Laurindo Ferreira da Rocha Junior; Andréa Tavares Dantas; Angela Luzia Branco Pinto Duarte; Moacyr Jesus Barreto de Melo Rego; Ivan da Rocha Pitta; Maira Galdino da Rocha Pitta
Journal:  PPAR Res       Date:  2013-08-01       Impact factor: 4.964

8.  Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.

Authors:  Adria Carbo; Josep Bassaganya-Riera; Mireia Pedragosa; Monica Viladomiu; Madhav Marathe; Stephen Eubank; Katherine Wendelsdorf; Keith Bisset; Stefan Hoops; Xinwei Deng; Maksudul Alam; Barbara Kronsteiner; Yongguo Mei; Raquel Hontecillas
Journal:  PLoS One       Date:  2013-09-05       Impact factor: 3.240

9.  Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection.

Authors:  Delphine Planas; Augustine Fert; Yuwei Zhang; Jean-Philippe Goulet; Jonathan Richard; Andrés Finzi; Maria Julia Ruiz; Laurence Raymond Marchand; Debashree Chatterjee; Huicheng Chen; Tomas Raul Wiche Salinas; Annie Gosselin; Eric A Cohen; Jean-Pierre Routy; Nicolas Chomont; Petronela Ancuta
Journal:  Pathog Immun       Date:  2020-09-30
  9 in total

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