UNLABELLED: Abstract Objectives. Several lines of evidence have shown that both RELN mRNA and protein are possibly down-regulated in the brain of schizophrenia patients. Recent association studies in European populations suggested RELN as a risk gene for schizophrenia. In this study, we test if RELN contributes to the risk of schizophrenia in Chinese population. Methods. We conducted case-control association analysis of 19 representative single nucleotide polymorphisms (SNPs) spanning the entire region of RELN in two independent Han Chinese samples from southwestern China (the Kunming sample and the Yuxi sample). Results. We identified six SNPs significantly associated with schizophrenia in the Kunming sample and four of them remained significant in the combined samples (the P values range from 0.006 to 4.0 × 10(-5)). Haplotype analysis also suggested significant associations for the haplotypes incorporating the six significant SNPs (global P < 1.0 × 10(-5)). Additionally, we also observed several other haplotypes (defined by a different set of SNPs) significantly associated with schizophrenia in the Kunming sample. However, the reported association of rs7341475 in Ashkenazi Jews was not significant in Han Chinese. CONCLUSIONS: Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
UNLABELLED: Abstract Objectives. Several lines of evidence have shown that both RELN mRNA and protein are possibly down-regulated in the brain of schizophreniapatients. Recent association studies in European populations suggested RELN as a risk gene for schizophrenia. In this study, we test if RELN contributes to the risk of schizophrenia in Chinese population. Methods. We conducted case-control association analysis of 19 representative single nucleotide polymorphisms (SNPs) spanning the entire region of RELN in two independent Han Chinese samples from southwestern China (the Kunming sample and the Yuxi sample). Results. We identified six SNPs significantly associated with schizophrenia in the Kunming sample and four of them remained significant in the combined samples (the P values range from 0.006 to 4.0 × 10(-5)). Haplotype analysis also suggested significant associations for the haplotypes incorporating the six significant SNPs (global P < 1.0 × 10(-5)). Additionally, we also observed several other haplotypes (defined by a different set of SNPs) significantly associated with schizophrenia in the Kunming sample. However, the reported association of rs7341475 in Ashkenazi Jews was not significant in Han Chinese. CONCLUSIONS: Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
Authors: Ming Li; Dong-Dong Wu; Yong-Gang Yao; Yong-Xia Huo; Jie-Wei Liu; Bing Su; Daniel I Chasman; Audrey Y Chu; Tao Huang; Lu Qi; Yan Zheng; Xiong-Jian Luo Journal: Schizophr Bull Date: 2015-05-25 Impact factor: 9.306
Authors: Ming Li; Liang Huang; Maria Grigoroiu-Serbanescu; Sarah E Bergen; Mikael Landén; Christina M Hultman; Andreas J Forstner; Jana Strohmaier; Julian Hecker; Thomas G Schulze; Bertram Müller-Myhsok; Andreas Reif; Philip B Mitchell; Nicholas G Martin; Sven Cichon; Markus M Nöthen; Anna Alkelai; Bernard Lerer; Stéphane Jamain; Marion Leboyer; Frank Bellivier; Bruno Etain; Jean-Pierre Kahn; Chantal Henry; Marcella Rietschel Journal: Mol Neurobiol Date: 2015-12-04 Impact factor: 5.590