| Literature DB >> 21744351 |
G M Lv1, P Li, W D Wang, Sh K Wang, J F Chen, Y L Gong.
Abstract
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid with diverse effects on various cells, ranging from immediate morphological change to long-lasting cellular function alteration such as induction of stimulation of cell proliferation, survival, drug resistance, and motility. LPA interacts with cells through specific cell surface receptors. LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7 are three most common LPA receptors. Herein we review the roles of LPA and its receptors in the carcinogenesis of human malignancies, with focus on pancreatic cancer.Entities:
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Year: 2011 PMID： 21744351 DOI： 10.1002/jso.22016
Source DB: PubMed Journal: J Surg Oncol ISSN： 0022-4790 Impact factor: 3.454