BACKGROUND: There are very few reports regarding the impact of the symptom that caused patients to consult a doctor and the symptom-to-diagnosis delay on survival for soft tissue sarcoma patients. The purpose of this study is to investigate whether symptom-treatment delay are associated with the presence of metastasis at diagnosis, overall survival and distant metastasis-free survival in primary soft tissue sarcomas. METHODS: This study retrospectively reviewed the medical records of 100 newly diagnosed patients with primary soft tissue sarcoma referred to our hospital. RESULTS: Eighteen of 100 sarcoma patients had distant metastases at diagnosis. A multivariate logistic regression analysis revealed that tumor size, tumor site, and the interval between the onset of the initial symptom and the first consultation to our hospital were all found to be significant predictors of distant metastases at diagnosis. The patients (n = 48) who were treated within the first 6 months from the onset of the initial symptom showed significantly better cumulative overall survival rate than those (n = 34) who were diagnosed more than 6 months (5-years: 77.0% vs. 59.7%). CONCLUSION: These results suggest that a shorter delay may have a beneficial effect on treatment options and outcome, improving survival in some sarcoma patients.
BACKGROUND: There are very few reports regarding the impact of the symptom that caused patients to consult a doctor and the symptom-to-diagnosis delay on survival for soft tissue sarcomapatients. The purpose of this study is to investigate whether symptom-treatment delay are associated with the presence of metastasis at diagnosis, overall survival and distant metastasis-free survival in primary soft tissue sarcomas. METHODS: This study retrospectively reviewed the medical records of 100 newly diagnosed patients with primary soft tissue sarcoma referred to our hospital. RESULTS: Eighteen of 100 sarcomapatients had distant metastases at diagnosis. A multivariate logistic regression analysis revealed that tumor size, tumor site, and the interval between the onset of the initial symptom and the first consultation to our hospital were all found to be significant predictors of distant metastases at diagnosis. The patients (n = 48) who were treated within the first 6 months from the onset of the initial symptom showed significantly better cumulative overall survival rate than those (n = 34) who were diagnosed more than 6 months (5-years: 77.0% vs. 59.7%). CONCLUSION: These results suggest that a shorter delay may have a beneficial effect on treatment options and outcome, improving survival in some sarcomapatients.
Authors: Jaqueline C Avila; J Andrew Livingston; Ana M Rodriguez; Anne C Kirchhoff; Yong-Fang Kuo; Sapna Kaul Journal: J Adolesc Young Adult Oncol Date: 2018-08-10 Impact factor: 2.223
Authors: Antonieta Medina-Lara; Bogdan Grigore; Ruth Lewis; Jaime Peters; Sarah Price; Paolo Landa; Sophie Robinson; Richard Neal; William Hamilton; Anne E Spencer Journal: Health Technol Assess Date: 2020-11 Impact factor: 4.014
Authors: Iris-Melanie Noebauer-Huhmann; Gabriele Amann; Martin Krssak; Joannis Panotopoulos; Pavol Szomolanyi; Michael Weber; Christian Czerny; Martin Breitenseher; Guenther Grabner; Wolfgang Bogner; Stefan Nemec; Martin Dominkus; Philipp Funovics; Reinhard Windhager; Siegfried Trattnig Journal: Eur Radiol Date: 2015-01-11 Impact factor: 5.315
Authors: R D Neal; P Tharmanathan; B France; N U Din; S Cotton; J Fallon-Ferguson; W Hamilton; A Hendry; M Hendry; R Lewis; U Macleod; E D Mitchell; M Pickett; T Rai; K Shaw; N Stuart; M L Tørring; C Wilkinson; B Williams; N Williams; J Emery Journal: Br J Cancer Date: 2015-03-31 Impact factor: 7.640