OBJECTIVE: The study addresses risk factors and cause of pediatric sensory over-responsivity (SOR) in a large sample of twins. At age 2 years, (a) the association of temperamental traits with concurrent SOR; (b) the association of prenatal complications with SOR; (c) the association of having a male cotwin with female SOR; and (d) the common and unique genetic causes of temperament and SOR symptoms are examined. METHODS: The sample included 1026 twin pairs (mean age = 2 years 2 months) from a population-based longitudinal study. Auditory and tactile SOR symptom domains were partially independent and thus were examined separately. RESULTS: Temperamental negative affect and fear were moderately correlated with auditory and tactile SOR symptoms. Prenatal complications significantly predicted tactile symptoms after controlling for child characteristics. In addition, females with a male cotwin showed greater SOR at age 2 years than same-sex female dizygotic twins, suggesting a possible risk associated with in utero testosterone exposure. Both auditory and tactile SOR domains were heritable. Bivariate genetic analyses showed that each SOR domain had a similar genetic relationship with fear and negative affect. CONCLUSION: The findings suggest partially nonoverlapping causes and risk factors for tactile versus auditory SOR and indicate that prenatal factors warrant further investigation.
OBJECTIVE: The study addresses risk factors and cause of pediatric sensory over-responsivity (SOR) in a large sample of twins. At age 2 years, (a) the association of temperamental traits with concurrent SOR; (b) the association of prenatal complications with SOR; (c) the association of having a male cotwin with female SOR; and (d) the common and unique genetic causes of temperament and SOR symptoms are examined. METHODS: The sample included 1026 twin pairs (mean age = 2 years 2 months) from a population-based longitudinal study. Auditory and tactile SOR symptom domains were partially independent and thus were examined separately. RESULTS: Temperamental negative affect and fear were moderately correlated with auditory and tactile SOR symptoms. Prenatal complications significantly predicted tactile symptoms after controlling for child characteristics. In addition, females with a male cotwin showed greater SOR at age 2 years than same-sex female dizygotic twins, suggesting a possible risk associated with in utero testosterone exposure. Both auditory and tactile SOR domains were heritable. Bivariate genetic analyses showed that each SOR domain had a similar genetic relationship with fear and negative affect. CONCLUSION: The findings suggest partially nonoverlapping causes and risk factors for tactile versus auditory SOR and indicate that prenatal factors warrant further investigation.
Authors: Nadine Forget-Dubois; Daniel Pérusse; Gustavo Turecki; Alain Girard; Jean-Michel Billette; Guy Rouleau; Michel Boivin; Jocelyn Malo; Richard E Tremblay Journal: Twin Res Date: 2003-12
Authors: L J Miller; D N McIntosh; J McGrath; V Shyu; M Lampe; A K Taylor; F Tassone; K Neitzel; T Stackhouse; R J Hagerman Journal: Am J Med Genet Date: 1999-04-02
Authors: Anna I Wagner; Nicole L Schmidt; Kathryn Lemery-Chalfant; Lewis A Leavitt; H Hill Goldsmith Journal: J Dev Behav Pediatr Date: 2009-06 Impact factor: 2.225
Authors: Nicole L Schmidt; Carol A Van Hulle; Rebecca J Brooker; Lauren R Meyer; Kathryn Lemery-Chalfant; H Hill Goldsmith Journal: Twin Res Hum Genet Date: 2012-11-15 Impact factor: 1.587
Authors: Mary L Schneider; Colleen F Moore; Miriam Adkins; Christina S Barr; Julie A Larson; Leslie M Resch; Andrew Roberts Journal: Child Dev Date: 2016-06-24
Authors: Ana Carolina Cabral de Paula Machado; Suelen Rosa de Oliveira; Lívia de Castro Magalhães; Débora Marques de Miranda; Maria Cândida Ferrarez Bouzada Journal: Rev Paul Pediatr Date: 2017-02-20