Literature DB >> 21741591

The role of TET2 in hematologic neoplasms.

Linda Holmfeldt1, Charles G Mullighan.   

Abstract

TET2 encodes an enzyme that hydroxylates methylcytosine and is frequently targeted by loss-of-function mutations in myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia. In this issue of Cancer Cell, two studies show that inactivation of Tet2 enhances hematopoietic stem cell self renewal and promotes the development of myeloproliferative disorders.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21741591     DOI： 10.1016/j.ccr.2011.06.025

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism.

Authors:  Rashim Pal Singh; Aaron D Schimmer
Journal:  Mol Cell Oncol       Date:  2020-09-28

2.  TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model.

Authors:  Liang Ge; Rui-peng Zhang; Feng Wan; Dong-yang Guo; Ping Wang; Li-xin Xiang; Jian-zhong Shao
Journal:  Mol Cell Biol       Date:  2014-01-06       Impact factor: 4.272

Review 3.  Comprehensive Analysis of Acquired Genetic Variants and Their Prognostic Impact in Systemic Mastocytosis.

Authors:  Oscar González-López; Javier I Muñoz-González; Alberto Orfao; Iván Álvarez-Twose; Andrés C García-Montero
Journal:  Cancers (Basel)       Date:  2022-05-18       Impact factor: 6.575

4.  Nanopores discriminate among five C5-cytosine variants in DNA.

Authors:  Zachary L Wescoe; Jacob Schreiber; Mark Akeson
Journal:  J Am Chem Soc       Date:  2014-11-14       Impact factor: 15.419

5.  Loss of Tet2 affects platelet function but not coagulation in mice.

Authors:  Bichen Wang; Meijuan Xia; Ting Chen; Mengke Li; Deyang Shi; Xiaomin Wang; Aiming Pang; Jiaxi Zhou; Weiping Yuan; Yajing Chu
Journal:  Blood Sci       Date:  2020-10-23

6.  Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer.

Authors:  Ursula M Schick; Andrew McDavid; Paul K Crane; Noah Weston; Kelly Ehrlich; Katherine M Newton; Robert Wallace; Ebony Bookman; Tabitha Harrison; Aaron Aragaki; David R Crosslin; Sophia S Wang; Alex P Reiner; Rebecca D Jackson; Ulrike Peters; Eric B Larson; Gail P Jarvik; Christopher S Carlson
Journal:  PLoS One       Date:  2013-03-22       Impact factor: 3.240

Review 7.  Genome-scale technology driven advances to research into normal and malignant haematopoiesis.

Authors:  Berthold Göttgens
Journal:  Scientifica (Cairo)       Date:  2012-12-31
  7 in total

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