BACKGROUND: The use of sentinel lymph node biopsy (SLNB) for ductal carcinoma in situ (DCIS) is controversial. METHODS: A total of 103 primary breast cancer patients who were diagnosed with DCIS by needle biopsy preoperatively and underwent initial SLNB were analyzed retrospectively. RESULTS: No sentinel nodal metastasis was detected in 66 patients with the final diagnosis of DCIS. However, 2 (5.4%) of 37 patients with invasive ductal carcinoma at final diagnosis had positive sentinel nodes. Multivariate logistic regression analysis identified 2 independent significant predictors of existence of invasive components: presence of a palpable tumor (odds ratio, 4.091; 95% confidential interval, 1.399-11.959; P = .010) and tumor size of 2.0 cm or larger on magnetic resonance imaging (odds ratio, 4.506; 95% confidence interval, 1.322-15.358; P = .016). CONCLUSIONS: Initial SLNB should be considered for patients diagnosed with DCIS by needle biopsy when they have a high risk for harboring invasive ductal cancer preoperatively.
BACKGROUND: The use of sentinel lymph node biopsy (SLNB) for ductal carcinoma in situ (DCIS) is controversial. METHODS: A total of 103 primary breast cancerpatients who were diagnosed with DCIS by needle biopsy preoperatively and underwent initial SLNB were analyzed retrospectively. RESULTS: No sentinel nodal metastasis was detected in 66 patients with the final diagnosis of DCIS. However, 2 (5.4%) of 37 patients with invasive ductal carcinoma at final diagnosis had positive sentinel nodes. Multivariate logistic regression analysis identified 2 independent significant predictors of existence of invasive components: presence of a palpable tumor (odds ratio, 4.091; 95% confidential interval, 1.399-11.959; P = .010) and tumor size of 2.0 cm or larger on magnetic resonance imaging (odds ratio, 4.506; 95% confidence interval, 1.322-15.358; P = .016). CONCLUSIONS: Initial SLNB should be considered for patients diagnosed with DCIS by needle biopsy when they have a high risk for harboring invasive ductal cancer preoperatively.
Authors: Ahmed Yahia Al-Ameer; Sahar Al Nefaie; Badria Al Johani; Ihab Anwar; Taher Al Tweigeri; Asma Tulbah; Mohmmed Alshabanah; Osama Al Malik Journal: World J Clin Oncol Date: 2016-04-10
Authors: Oldřich Coufal; Iveta Selingerová; Pavlína Vrtělová; Petr Krsička; Lucie Gabrielová; Pavel Fabian; Kateřina Stískalová; Monika Schneiderová; Alexandr Poprach; Ivan Justan Journal: Biomed Res Int Date: 2014-07-08 Impact factor: 3.411
Authors: Suzanne C E Diepstraten; Stephanie M W Y van de Ven; Ruud M Pijnappel; Petra H M Peeters; Maurice A A J van den Bosch; Helena M Verkooijen; Sjoerd G Elias Journal: PLoS One Date: 2013-10-11 Impact factor: 3.240