Literature DB >> 217398

Effects of Corynebacterium parvum on murine myeloid leukaemia.

S Bjornsson, H Preisler, Z Pavelic.   

Abstract

The effects of C. parvum on RFM/UN myeloid leukaemia were studied. Mice inoculated with 7.0 mg but not 0.7 mg C. parvum i.p. survived significantly longer than untreated leukaemic mice (P less than 0.001). Administration of silica abrogated the effects of C. parvum, whilst polyvinyl pyridine-N-oxide prevented the inhibitory effects of silica. These studies demonstrate that a single large dose of C. parvum, either before or after leukaemic-cell passage, can significantly prolong the survival of RFM mice bearing myeloid leukaemia. The effects of silica and PVNO on C. parvum suggest a critical role for macrophages in C. parvum effects on myeloid leukaemia.

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Year:  1978        PMID： 217398      PMCID： PMC2009826          DOI： 10.1038/bjc.1978.276

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  18 in total

1.  Natural cell-mediated cytotoxicity in rats. III. Effects of immunopharmacologic treatments on natural reactivity and on reactivity augmented by polyinosinic-polycytidylic acid.

Authors:  J R Oehler; R B Herberman
Journal:  Int J Cancer       Date:  1978-02-15       Impact factor: 7.396

2.  Abrogation of antitumor effects of Corynebacterium parvum and BCG by antimacrophage agents: brief communication.

Authors:  R Keller
Journal:  J Natl Cancer Inst       Date:  1977-12       Impact factor: 13.506

3.  Local control and disease-free survival after treatment of a squamous cell carcinoma by Corynebacterium parvum and local irradiation.

Authors:  H D Suit; R Sedlacek; V Silobrcic
Journal:  Cancer Res       Date:  1977-11       Impact factor: 12.701

4.  In vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with Corynebacterium parvum: reduced effect in irradiated recipients.

Authors:  L J Peters; W H McBride; K A Mason; N Hunter; I Basić; L Milas
Journal:  J Natl Cancer Inst       Date:  1977-09       Impact factor: 13.506

Review 5.  Corynebacterium parvum as an immunotherapeutic anticancer agent.

Authors:  M T Scott
Journal:  Semin Oncol       Date:  1974-12       Impact factor: 4.929

6.  Effects of Corynebacterium parvum alone and in combination with adriamycin in experimental tumor systems.

Authors:  D P Houchens; R K Johnson; A Ovejera; M R Gaston; A Goldin
Journal:  Cancer Treat Rep       Date:  1976-07

7.  Intravascular coagulation resulting from intravenous injection of C. parvum in mice.

Authors:  I A Lampert; P D Jones; T E Sadler; J E Castro
Journal:  Br J Cancer       Date:  1977-07       Impact factor: 7.640

8.  Natural cell-mediated cytotoxicity in rats. II. In vivo augmentation of NK-cell activity.

Authors:  J R Oehler; L R Lindsay; M E Nunn; H T Holden; R B Herberman
Journal:  Int J Cancer       Date:  1978-02-15       Impact factor: 7.396

9.  Murine myeloid leukemia: I. Pathophysiology and drug sensitivity.

Authors:  H D Preisler; S Bjornsson; M Mori
Journal:  Cancer Treat Rep       Date:  1977-10

10.  Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum.

Authors:  P D Jones; J E Castro
Journal:  Br J Cancer       Date:  1977-05       Impact factor: 7.640
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  1 in total

1.  Adjuvant immune stimulation with Corynebacterium parvum during maintenance chemotherapy of acute myeloid leukemia. A prospective randomized study.

Authors:  E la Cour Petersen; P Hokland; J Ellegaard
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968
  1 in total

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