Literature DB >> 2173960

Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus.

V Tancredi1, C Zona, F Velotti, F Eusebi, A Santoni.   

Abstract

The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.

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Year:  1990        PMID： 2173960     DOI： 10.1016/0006-8993(90)91331-a

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

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