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Literature DB >> 21738150

Bronchodilator activity of bitter tastants in human tissue.

Deepak A Deshpande¹, Kathryn S Robinett, Wayne C H Wang, James S K Sham, Steven S An, Stephen B Liggett.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Bronchodilator Agents

Year: 2011 PMID： 21738150 PMCID： PMC4576926 DOI： 10.1038/nm0711-776b

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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4 in total

1. The molecular receptive ranges of human TAS2R bitter taste receptors.

Authors: Wolfgang Meyerhof; Claudia Batram; Christina Kuhn; Anne Brockhoff; Elke Chudoba; Bernd Bufe; Giovanni Appendino; Maik Behrens
Journal: Chem Senses Date: 2009-12-18 Impact factor: 3.160

2. Effect of indacaterol, a novel long-acting beta2-agonist, on isolated human bronchi.

Authors: E Naline; A Trifilieff; R A Fairhurst; C Advenier; M Molimard
Journal: Eur Respir J Date: 2006-11-29 Impact factor: 16.671

3. Relaxant effects and durations of action of formoterol and salmeterol on the isolated human bronchus.

Authors: E Naline; Y Zhang; Y Qian; N Mairon; G P Anderson; B Grandordy; C Advenier
Journal: Eur Respir J Date: 1994-05 Impact factor: 16.671

4. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Authors: Deepak A Deshpande; Wayne C H Wang; Elizabeth L McIlmoyle; Kathryn S Robinett; Rachel M Schillinger; Steven S An; James S K Sham; Stephen B Liggett
Journal: Nat Med Date: 2010-10-24 Impact factor: 53.440

4 in total

16 in total

1. Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G_αi1,2,3.

Authors: Donghwa Kim; Jung A Woo; Ezekiel Geffken; Steven S An; Stephen B Liggett
Journal: Am J Respir Cell Mol Biol Date: 2017-06 Impact factor: 6.914

2. Differential long-term regulation of TAS2R14 by structurally distinct agonists.

Authors: Jung A Woo; Maria Castaño; Ashley Goss; Donghwa Kim; Eric M Lewandowski; Yu Chen; Stephen B Liggett
Journal: FASEB J Date: 2019-08-20 Impact factor: 5.191

3. Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2.

Authors: Donghwa Kim; Soomin Cho; Maria A Castaño; Reynold A Panettieri; Jung A Woo; Stephen B Liggett
Journal: Am J Respir Cell Mol Biol Date: 2019-05 Impact factor: 6.914

4. Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma.

Authors: Stephen B Liggett
Journal: Trans Am Clin Climatol Assoc Date: 2014

5. Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5.

Authors: Donghwa Kim; Steven S An; Hong Lam; James W Leahy; Stephen B Liggett
Journal: ACS Pharmacol Transl Sci Date: 2020-11-05

9. Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.

Authors: Moon Young Yang; Soo-Kyung Kim; Donghwa Kim; Stephen B Liggett; William A Goddard
Journal: J Phys Chem Lett Date: 2021-09-20 Impact factor: 6.888

Review 10. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators.

Authors: Stephen B Liggett
Journal: Expert Opin Ther Targets Date: 2013-04-12 Impact factor: 6.902