Literature DB >> 2173798

naf, a trans-regulating negative-acting factor encoded within the mouse mammary tumor virus open reading frame region.

B Salmons1, V Erfle, G Brem, W H Günzburg.   

Abstract

The mouse mammary tumor virus (MMTV) long terminal repeat (LTR) open reading frame (ORF) encodes a negative acting factor (naf). In our test system, naf mediates its effect in trans on another MMTV provirus in which the 5' LTR has been replaced by that of Rous sarcoma virus. naf effects are evidenced at the level of transcriptional initiation rather than as reduced mRNA stability. The introduction of a premature termination codon into the MMTV LTR-encoded ORF abolishes the transcriptional down regulation localizing naf within the ORF. In addition, sequences in the gag/pol genes between +320 and +646 and between +3626 and +4590 relative to the site of transcription initiation are also involved in the MMTV-mediated transcriptional down regulation.

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Year:  1990        PMID： 2173798      PMCID： PMC248820          DOI： 10.1128/JVI.64.12.6355-6359.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

2.  Prediction of protein antigenic determinants from amino acid sequences.

Authors:  T P Hopp; K R Woods
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

3.  Long terminal repeats of endogenous mouse mammary tumour virus contain a long open reading frame which extends into adjacent sequences.

Authors:  N Kennedy; G Knedlitschek; B Groner; N E Hynes; P Herrlich; R Michalides; A J van Ooyen
Journal:  Nature       Date:  1982-02-18       Impact factor: 49.962

4.  In vitro synthesis of polypeptides encoded by the long terminal repeat region of mouse mammary tumour virus DNA.

Authors:  C Dickson; R Smith; G Peters
Journal:  Nature       Date:  1981-06-11       Impact factor: 49.962

5.  Protein-coding potential of mouse mammary tumor virus genome RNA as examined by in vitro translation.

Authors:  C Dickson; G Peters
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

6.  Synthesis of murine mammary tumor viral proteins in vitro.

Authors:  G C Sen; J Racevskis; N H Sarkar
Journal:  J Virol       Date:  1981-03       Impact factor: 5.103

7.  Transcription of mouse mammary tumor virus: identification of a candidate mRNA for the long terminal repeat gene product.

Authors:  D A Wheeler; J S Butel; D Medina; R D Cardiff; G L Hager
Journal:  J Virol       Date:  1983-04       Impact factor: 5.103

8.  Structural analysis of a 1.7-kilobase mouse mammary tumor virus-specific RNA.

Authors:  A J van Ooyen; R J Michalides; R Nusse
Journal:  J Virol       Date:  1983-05       Impact factor: 5.103

9.  Proteins encoded by the long terminal repeat region of mouse mammary tumor virus: identification by hybrid-selected translation.

Authors:  J Racevskis; O Prakash
Journal:  J Virol       Date:  1984-09       Impact factor: 5.103

10.  Bovine leukemia virus trans-activator p38tax activates heterologous promoters with a common sequence known as a cAMP-responsive element or the binding site of a cellular transcription factor ATF.

Authors:  I Katoh; Y Yoshinaka; Y Ikawa
Journal:  EMBO J       Date:  1989-02       Impact factor: 11.598
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  11 in total

Review 1.  Factors controlling the expression of mouse mammary tumour virus.

Authors:  W H Günzburg; B Salmons
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

Review 2.  Bacterial and viral superantigens: roles in autoimmunity?

Authors:  H Acha-Orbea
Journal:  Ann Rheum Dis       Date:  1993-03       Impact factor: 19.103

3.  Negative-acting factor and superantigen are separable activities of the mouse mammary tumor virus long terminal repeat.

Authors:  S Wintersperger; B Salmons; T Miethke; V Erfle; H Wagner; W H Günzburg
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

4.  Selection for c-myc integration sites in polyclonal T-cell lymphomas.

Authors:  Dana R Broussard; Jennifer A Mertz; M Lozano; Jaquelin P Dudley
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

Review 5.  MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.

Authors:  Susan R Ross
Journal:  J Mammary Gland Biol Neoplasia       Date:  2008-07-26       Impact factor: 2.673

6.  Detection and characterization of a glycoprotein encoded by the mouse mammary tumor virus long terminal repeat gene.

Authors:  C Brandt-Carlson; J S Butel
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

7.  An activation-dependent, T-lymphocyte-specific transcriptional activator in the mouse mammary tumor virus env gene.

Authors:  C L Miller; R Garner; V Paetkau
Journal:  Mol Cell Biol       Date:  1992-07       Impact factor: 4.272

8.  Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7.

Authors:  U Beutner; W N Frankel; M S Cote; J M Coffin; B T Huber
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

9.  Cross-packaging of genetically distinct mouse and primate retroviral RNAs.

Authors:  Noura Salem Al Dhaheri; Pretty Susan Phillip; Akela Ghazawi; Jahabar Ali; Elizabeth Beebi; Soumeya Ali Jaballah; Tahir A Rizvi
Journal:  Retrovirology       Date:  2009-07-14       Impact factor: 4.602

10.  Identification of diverse full-length endogenous betaretroviruses in megabats and microbats.

Authors:  Joshua A Hayward; Mary Tachedjian; Jie Cui; Hume Field; Edward C Holmes; Lin-Fa Wang; Gilda Tachedjian
Journal:  Retrovirology       Date:  2013-03-27       Impact factor: 4.602
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