BACKGROUND AND PURPOSE: Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS: We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS: Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. CONCLUSIONS: These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
BACKGROUND AND PURPOSE: Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS: We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS: Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion. CONCLUSIONS: These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
Authors: Heidi Johansen-Berg; Matthew F S Rushworth; Marko D Bogdanovic; Udo Kischka; Sunil Wimalaratna; Paul M Matthews Journal: Proc Natl Acad Sci U S A Date: 2002-10-10 Impact factor: 11.205
Authors: R Hanajima; Y Ugawa; K Machii; H Mochizuki; Y Terao; H Enomoto; T Furubayashi; Y Shiio; H Uesugi; I Kanazawa Journal: J Physiol Date: 2001-03-15 Impact factor: 5.182