Literature DB >> 21737438

Simulating systems genetics data with SysGenSIM.

Andrea Pinna1, Nicola Soranzo, Ina Hoeschele, Alberto de la Fuente.   

Abstract

SUMMARY: SysGenSIM is a software package to simulate Systems Genetics (SG) experiments in model organisms, for the purpose of evaluating and comparing statistical and computational methods and their implementations for analyses of SG data [e.g. methods for expression quantitative trait loci (eQTL) mapping and network inference]. SysGenSIM allows the user to select a variety of network topologies, genetic and kinetic parameters to simulate SG data ( genotyping, gene expression and phenotyping) with large gene networks with thousands of nodes. The software is encoded in MATLAB, and a user-friendly graphical user interface is provided. AVAILABILITY: The open-source software code and user manual can be downloaded at: http://sysgensim.sourceforge.net/ CONTACT: alf@crs4.it.

Mesh：

Year:  2011        PMID： 21737438      PMCID： PMC3157927          DOI： 10.1093/bioinformatics/btr407

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


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8.  Reconstruction of large-scale regulatory networks based on perturbation graphs and transitive reduction: improved methods and their evaluation.

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