| Literature DB >> 21737285 |
Maki Iwahashi1, Atsushi Shimabukuro, Takahiro Onoda, Yoko Matsunaga, Yutaka Okada, Ryoji Matsumoto, Fumio Nambu, Hisao Nakai, Masaaki Toda.
Abstract
A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.Entities:
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Year: 2011 PMID： 21737285 DOI： 10.1016/j.bmc.2011.06.014
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641