| Literature DB >> 21737271 |
Xiao Hu1, Jun Ji, Meng Wang, Jin-Wei Wu, Qin-Shi Zhao, He-Yao Wang, Ai-Jun Hou.
Abstract
Five new isoprenylated flavonoids, notabilisins A-E (1-5), and two known Diels-Alder adducts (6 and 7), were isolated from the twigs of Morus notabilis. Compounds 4 and 5 possess two novel pyran rings, which may be biogenetically derived from 3. Compounds 1 and 3 significantly promoted adipogenesis, characterized by increased lipid droplet and triglyceride content in 3T3L1 cells, and induced up-regulation of the expression of adipocyte-specific genes, aP2 and GLUT4.Entities:
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Year: 2011 PMID： 21737271 DOI： 10.1016/j.bmcl.2011.06.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823