Linda Schmitz1, Shirish Prayag2, Sunitha Varghese3, Sameer Jog4, Pallavi Bhargav-Patil4, Ajit Yadav3, Deepak Salunke3, Jean-Louis Vincent5. 1. Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Belgium. 2. Prayag Hospital-Shree Medical Foundation, Pune, India. 3. Niramaya Hospital, Chinchwad, Pune, India. 4. Deenanath Mangeshkar Hospital, Pune, India. 5. Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Belgium. Electronic address: jlvincen@ulb.ac.be.
Abstract
PURPOSE: The purpose of the study was to explore determinants of outcome in adults with dengue hemorrhagic fever or dengue shock syndrome. METHODS: We performed a multicenter, retrospective, observational study over a 2-year period in 3 intensive care units (ICUs) in Pune (India). RESULTS: One hundred eighty-four adult patients were admitted to the ICU with a positive dengue immunoglobulin M test result; 43 met the World Health Organization criteria for dengue hemorrhagic fever or dengue shock syndrome. One patient who was transferred to another hospital and whose outcome was unknown was not included in the analysis. Of the 42 patients, 20 (48%) had multiorgan failure on ICU admission. The ICU mortality was 19% (8/42). Nonsurvivors were more likely than survivors to have cardiovascular (100% vs 12%), respiratory (88% vs 12%), or neurological (75% vs 12%) failure (all P < .01). Hematological failure was not associated with a higher risk of death. Cumulative fluid balance at 72 hours was more positive in nonsurvivors than in survivors (6.2 vs 3.5 L, P < .05). Serum albumin concentrations at ICU admission were lower in nonsurvivors than in survivors (2.9 ± 0.3 vs 3.4 ± 0.7 g/dL, P < .05). CONCLUSIONS: In our cohort, outcome from severe dengue was primarily related to nonhematological organ failure. Low serum albumin concentration on ICU admission and a more positive fluid balance at 72 hours were also associated with worse outcomes.
PURPOSE: The purpose of the study was to explore determinants of outcome in adults with dengue hemorrhagic fever or dengue shock syndrome. METHODS: We performed a multicenter, retrospective, observational study over a 2-year period in 3 intensive care units (ICUs) in Pune (India). RESULTS: One hundred eighty-four adult patients were admitted to the ICU with a positive dengue immunoglobulin M test result; 43 met the World Health Organization criteria for dengue hemorrhagic fever or dengue shock syndrome. One patient who was transferred to another hospital and whose outcome was unknown was not included in the analysis. Of the 42 patients, 20 (48%) had multiorgan failure on ICU admission. The ICU mortality was 19% (8/42). Nonsurvivors were more likely than survivors to have cardiovascular (100% vs 12%), respiratory (88% vs 12%), or neurological (75% vs 12%) failure (all P < .01). Hematological failure was not associated with a higher risk of death. Cumulative fluid balance at 72 hours was more positive in nonsurvivors than in survivors (6.2 vs 3.5 L, P < .05). Serum albumin concentrations at ICU admission were lower in nonsurvivors than in survivors (2.9 ± 0.3 vs 3.4 ± 0.7 g/dL, P < .05). CONCLUSIONS: In our cohort, outcome from severe dengue was primarily related to nonhematological organ failure. Low serum albumin concentration on ICU admission and a more positive fluid balance at 72 hours were also associated with worse outcomes.
Authors: Elzinandes Leal Azeredo; Flavia Barreto Dos Santos; Luciana Santos Barbosa; Thiara Manuele Alves Souza; Jessica Badolato-Corrêa; Juan Camilo Sánchez-Arcila; Priscila Conrado Guerra Nunes; Luzia Maria de-Oliveira-Pinto; Ana Maria de Filippis; Márcia Dal Fabbro; Izilyanne Hoscher Romanholi; Rivaldo Venancio da Cunha Journal: PLoS Curr Date: 2018-02-15