Giacomo Levantesi1, RosaMaria Marfisi1, Dariush Mozaffarian2, Maria Grazia Franzosi3, AldoPietro Maggioni4, Gian Luigi Nicolosi5, Carlo Schweiger6, MariaGiuseppina Silletta1, Luigi Tavazzi7, Gianni Tognoni1, Roberto Marchioli8. 1. Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy. 2. Departments of Medicine, Epidemiology, and Nutrition, Harvard Medical School and Harvard School of Public Health, Boston, MA, United States. 3. Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. 4. ANMCO Research Centre, Florence, Italy. 5. AO S. Maria Angeli, Pordenone, Italy. 6. OC Passirana di Rho, Milan, Italy. 7. GVM Hospitals of Care and Research, Cotignola, Italy. 8. Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy. Electronic address: marchioli@negrisud.it.
Abstract
BACKGROUND: To evaluate the association of wine intake with incident cardiovascular events (CVE) and total mortality after myocardial infarction (MI). METHODS: We used prospectively ascertained information among 11,248 Italian patients with recent MI enrolled in the GISSI-Prevenzione Trial. Usual wine consumption has been categorised as never/almost never, up to 0.5L/day, and >0.5L/day. Multiple imputation was used for missing values at baseline and during follow-up. We assessed adjudicated cumulative incidence of major CVE during 3.5years of follow-up and total mortality at long-term follow-up (7.3years), respectively. Multivariate Cox proportional hazards models were fitted to estimate hazard ratios (HR) first using data at baseline and then updated using time-varying covariates. RESULTS: During 37,021 person-years of follow-up, 1168 CVE occurred. Moderate wine intake at baseline was associated with significantly reduced risk of CVE (adjusted HR 0.87; 95% CI 0.76-0.99) as compared with non-drinkers. In time-updated analyses, results were virtually the same, though they were barely statistically not significant (adjusted HR 0.88; 95% CI 0.77-1.00). Wine intake was associated with lower risk of total mortality. In time-updated adjusted analyses, patients with wine consumption up to 0.5L/day (HR 0.83; 95% CI 0.74-0.92) and >0.5L/day (HR 0.77; 95% CI 0.63-0.94) had lower mortality compared with non-drinkers (P for trend=0.0003). CONCLUSIONS: Among patients with established heart disease, moderate consumption of wine seems to be associated with lower incidence of CVE and total mortality as compared with non drinkers.
RCT Entities:
BACKGROUND: To evaluate the association of wine intake with incident cardiovascular events (CVE) and total mortality after myocardial infarction (MI). METHODS: We used prospectively ascertained information among 11,248 Italian patients with recent MI enrolled in the GISSI-Prevenzione Trial. Usual wine consumption has been categorised as never/almost never, up to 0.5L/day, and >0.5L/day. Multiple imputation was used for missing values at baseline and during follow-up. We assessed adjudicated cumulative incidence of major CVE during 3.5years of follow-up and total mortality at long-term follow-up (7.3years), respectively. Multivariate Cox proportional hazards models were fitted to estimate hazard ratios (HR) first using data at baseline and then updated using time-varying covariates. RESULTS: During 37,021 person-years of follow-up, 1168 CVE occurred. Moderate wine intake at baseline was associated with significantly reduced risk of CVE (adjusted HR 0.87; 95% CI 0.76-0.99) as compared with non-drinkers. In time-updated analyses, results were virtually the same, though they were barely statistically not significant (adjusted HR 0.88; 95% CI 0.77-1.00). Wine intake was associated with lower risk of total mortality. In time-updated adjusted analyses, patients with wine consumption up to 0.5L/day (HR 0.83; 95% CI 0.74-0.92) and >0.5L/day (HR 0.77; 95% CI 0.63-0.94) had lower mortality compared with non-drinkers (P for trend=0.0003). CONCLUSIONS: Among patients with established heart disease, moderate consumption of wine seems to be associated with lower incidence of CVE and total mortality as compared with non drinkers.