Literature DB >> 21736809

Immunostimulatory effect of faecal Bifidobacterium species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system.

T Pozo-Rubio1, J R Mujico, A Marcos, E Puertollano, I Nadal, Y Sanz, E Nova.   

Abstract

Bifidobacterium spp. typical of the human intestinal microbiota are believed to influence the balance of immune responses in the intestinal mucosa. The aim of the present study was to investigate the effect of different bifidobacterial species and their mixtures in in vitro experiments with peripheral blood mononuclear cells (PBMC) and Caco-2 cells. Bifidobacterium adolescentis, B. angulatum, B. breve, B. catenulatum, B. infantis, B. longum and two combinations of these bifidobacteria simulating the species composition found in faecal samples from breast-fed (BF) and formula-fed (FF) infants were used. The levels of several cytokines were measured by direct stimulation of PBMC and by stimulation of a Caco-2/PBMC co-culture with bifidobacteria. B. catenulatum and B. breve were the strongest enhancers of interferon-γ (IFN-γ) production by direct stimulation of PBMC. B. longum was the highest inducer of IL-10 and the lowest TNF-α stimulus. In the Caco-2/PBMC system, B. breve was the highest inducer of IL-8 production by Caco-2 cells, significantly different from B. infantis, B. adolescentis and the FF mixture (P < 0·05). IFN-γ produced by PBMC stimulated with the BF mixture (containing 22 % B. breve, compared with 7 % in the FF mixture) was significantly higher compared with B. adolescentis, B. infantis and B. longum. B. adolescentis also inhibited IFN-γ production compared with the FF mixture and B. longum. The proportion of different Bifidobacterium strains seems to be an important determinant of the cytokine balance in the simulated intestinal environment studied. B. breve and the combination of the Bifidobacterium species typically found in the microbiota of BF infants have shown the most significant effects.

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Year:  2011        PMID: 21736809     DOI: 10.1017/S0007114511001656

Source DB:  PubMed          Journal:  Br J Nutr        ISSN: 0007-1145            Impact factor:   3.718


  16 in total

1.  Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function.

Authors:  Maciej Chichlowski; Guillaume De Lartigue; J Bruce German; Helen E Raybould; David A Mills
Journal:  J Pediatr Gastroenterol Nutr       Date:  2012-09       Impact factor: 2.839

2.  Protective effects of bifidobacterial adhesin on intestinal mucosa of stressed male rats via modulation of inflammation.

Authors:  Xiao-Liang Shu; Tin-Tin Yu; Kai Kang; Han Xu; Tao Lei
Journal:  Int J Clin Exp Pathol       Date:  2014-05-15

3.  Inflammatory Responses of Porcine MoDC and Intestinal Epithelial Cells in a Direct-Contact Co-culture System Following a Bacterial Challenge.

Authors:  Henriette Loss; Jörg R Aschenbach; Friederike Ebner; Karsten Tedin; Ulrike Lodemann
Journal:  Inflammation       Date:  2020-04       Impact factor: 4.092

4.  Bifidobacterium bifidum PRL2010 modulates the host innate immune response.

Authors:  Francesca Turroni; Valentina Taverniti; Patricia Ruas-Madiedo; Sabrina Duranti; Simone Guglielmetti; Gabriele Andrea Lugli; Laura Gioiosa; Paola Palanza; Abelardo Margolles; Douwe van Sinderen; Marco Ventura
Journal:  Appl Environ Microbiol       Date:  2013-11-15       Impact factor: 4.792

Review 5.  Intestinal Barrier and Permeability in Health, Obesity and NAFLD.

Authors:  Piero Portincasa; Leonilde Bonfrate; Mohamad Khalil; Maria De Angelis; Francesco Maria Calabrese; Mauro D'Amato; David Q-H Wang; Agostino Di Ciaula
Journal:  Biomedicines       Date:  2021-12-31

6.  Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains.

Authors:  María José Fábrega; Laura Aguilera; Rosa Giménez; Encarna Varela; María Alexandra Cañas; María Antolín; Josefa Badía; Laura Baldomà
Journal:  Front Microbiol       Date:  2016-05-11       Impact factor: 5.640

Review 7.  Bifidobacteria and Their Molecular Communication with the Immune System.

Authors:  Lorena Ruiz; Susana Delgado; Patricia Ruas-Madiedo; Borja Sánchez; Abelardo Margolles
Journal:  Front Microbiol       Date:  2017-12-04       Impact factor: 5.640

8.  Genome Structure of the Symbiont Bifidobacterium pseudocatenulatum CECT 7765 and Gene Expression Profiling in Response to Lactulose-Derived Oligosaccharides.

Authors:  Alfonso Benítez-Páez; F Javier Moreno; María L Sanz; Yolanda Sanz
Journal:  Front Microbiol       Date:  2016-04-29       Impact factor: 5.640

Review 9.  Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health.

Authors:  Charlotte Grootaert; Senem Kamiloglu; Esra Capanoglu; John Van Camp
Journal:  Nutrients       Date:  2015-11-11       Impact factor: 5.717

Review 10.  The role of Gut Microbiota in the development of obesity and Diabetes.

Authors:  Othman A Baothman; Mazin A Zamzami; Ibrahim Taher; Jehad Abubaker; Mohamed Abu-Farha
Journal:  Lipids Health Dis       Date:  2016-06-18       Impact factor: 3.876

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