Literature DB >> 2173572

Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells.

Y Sato1, M Abe, R Takaki.   

Abstract

Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five micrograms/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 micrograms/ml of PF-4, where the binding of bFGF to the receptor was completely blocked.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2173572     DOI： 10.1016/0006-291x(90)90715-y

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

Review 1.  Antiangiogenesis as a novel therapeutic concept in pediatric oncology.

Authors:  L Schweigerer
Journal:  J Mol Med (Berl)       Date:  1995-10       Impact factor: 4.599

2.  Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity.

Authors:  P Romagnani; F Annunziato; L Lasagni; E Lazzeri; C Beltrame; M Francalanci; M Uguccioni; G Galli; L Cosmi; L Maurenzig; M Baggiolini; E Maggi; S Romagnani; M Serio
Journal:  J Clin Invest       Date:  2001-01       Impact factor: 14.808

3.  Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.

Authors:  Megan S Lord; Bill Cheng; Brooke L Farrugia; Simon McCarthy; John M Whitelock
Journal:  J Biol Chem       Date:  2017-01-23       Impact factor: 5.157

Review 4.  The role of chemokines and their receptors in angiogenesis.

Authors:  Friedemann Kiefer; Arndt F Siekmann
Journal:  Cell Mol Life Sci       Date:  2011-04-09       Impact factor: 9.261

5.  Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arginine residues are crucial for binding.

Authors:  K H Mayo; E Ilyina; V Roongta; M Dundas; J Joseph; C K Lai; T Maione; T J Daly
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

6.  Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.

Authors:  I Clark-Lewis; B Dewald; T Geiser; B Moser; M Baggiolini
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

7.  Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor.

Authors:  J B Watson; S B Getzler; D F Mosher
Journal:  J Clin Invest       Date:  1994-07       Impact factor: 14.808

8.  Heparin-induced thrombocytopenia in the pediatric population: a review of current literature.

Authors:  Niyati H Vakil; Abir O Kanaan; Jennifer L Donovan
Journal:  J Pediatr Pharmacol Ther       Date:  2012-01

Review 9.  Angiogenesis and antiangiogenic strategies in pancreatic cancer.

Authors:  William E Fisher; David H Berger
Journal:  Int J Gastrointest Cancer       Date:  2003

10.  Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo.

Authors:  Longjiang Yang; Juan Du; Jian Hou; Hua Jiang; Jianfeng Zou
Journal:  BMC Cancer       Date:  2011-06-21       Impact factor: 4.430
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.