AIM: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS: A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS: The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION: The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
AIM: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS: A hospital-based case-control study was conducted, including 307 gastric cancerpatients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay. RESULTS: The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancerpatients. CONCLUSION: The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
Authors: B Felding-Habermann; T E O'Toole; J W Smith; E Fransvea; Z M Ruggeri; M H Ginsberg; P E Hughes; N Pampori; S J Shattil; A Saven; B M Mueller Journal: Proc Natl Acad Sci U S A Date: 2001-02-13 Impact factor: 11.205
Authors: P M Dodson; J Haynes; J Starczynski; J Farmer; S Shigdar; G Fegan; R J Johnson; C Fegan Journal: Eye (Lond) Date: 2003-08 Impact factor: 3.775
Authors: Francisco Ayala; Javier Corral; Rocío González-Conejero; Ignacio Sánchez; José María Moraleda; Vicente Vicente Journal: Breast Cancer Res Treat Date: 2003-07 Impact factor: 4.872