BACKGROUND: Osteoporosis is a common complication of cystic fibrosis. OBJECTIVE: To determine the prevalence of osteopenia and osteoporosis in adults with cystic fibrosis and to look for factors associated with low bone mineral density (BMD) values. METHODS: During this prospective 2-year study, we collected clinical data (history, body mass index, and treatments) and laboratory data (nutritional and hormonal status, markers for inflammation and bone turnover, and calcium and phosphate levels). Lung function tests and a 6-meter walking test were performed. BMD was measured at the spine, total hip, and femoral neck. RESULTS: We included 55 patients (31 women) with a mean age of 31.9 years; 14 were homozygous and 25 heterozygous for the deltaF508 mutation and 20 (36%) had a history of fractures. BMD values indicated osteopenia in 32 (58.2%) patients and osteoporosis in 11 (20%) patients at one or more measurement sites. At all three sites, BMD values correlated with the body mass index, forced vital capacity as % predicted, and forced expiratory volume in 1 s as % predicted; at the femoral neck and total hip, BMD values correlated with the 6-meter walking test result and grip strength. CONCLUSION: BMD was low in 78.2% of adults with cystic fibrosis. Three factors reflecting lung disease severity were associated with low BMD values, namely, respiratory function, physical function (walking test and grip strength), and nutritional status.
BACKGROUND:Osteoporosis is a common complication of cystic fibrosis. OBJECTIVE: To determine the prevalence of osteopenia and osteoporosis in adults with cystic fibrosis and to look for factors associated with low bone mineral density (BMD) values. METHODS: During this prospective 2-year study, we collected clinical data (history, body mass index, and treatments) and laboratory data (nutritional and hormonal status, markers for inflammation and bone turnover, and calcium and phosphate levels). Lung function tests and a 6-meter walking test were performed. BMD was measured at the spine, total hip, and femoral neck. RESULTS: We included 55 patients (31 women) with a mean age of 31.9 years; 14 were homozygous and 25 heterozygous for the deltaF508 mutation and 20 (36%) had a history of fractures. BMD values indicated osteopenia in 32 (58.2%) patients and osteoporosis in 11 (20%) patients at one or more measurement sites. At all three sites, BMD values correlated with the body mass index, forced vital capacity as % predicted, and forced expiratory volume in 1 s as % predicted; at the femoral neck and total hip, BMD values correlated with the 6-meter walking test result and grip strength. CONCLUSION: BMD was low in 78.2% of adults with cystic fibrosis. Three factors reflecting lung disease severity were associated with low BMD values, namely, respiratory function, physical function (walking test and grip strength), and nutritional status.
Authors: D Gensburger; S Boutroy; R Chapurlat; R Nove-Josserand; S Roche; M Rabilloud; I Durieu Journal: Osteoporos Int Date: 2016-05-11 Impact factor: 4.507
Authors: E Cairoli; C Eller-Vainicher; L C Morlacchi; P Tarsia; V Rossetti; M Pappalettera; M Arosio; I Chiodini; F Blasi Journal: Osteoporos Int Date: 2019-02-23 Impact factor: 4.507
Authors: Melissa S Putman; Joshua F Baker; Ahmet Uluer; Karen Herlyn; Allen Lapey; Leonard Sicilian; Angela Pizzo Tillotson; Catherine M Gordon; Peter A Merkel; Joel S Finkelstein Journal: J Cyst Fibros Date: 2015-02-16 Impact factor: 5.482
Authors: M S Putman; L B Greenblatt; L Sicilian; A Uluer; A Lapey; G Sawicki; C M Gordon; M L Bouxsein; J S Finkelstein Journal: Osteoporos Int Date: 2016-03-07 Impact factor: 4.507
Authors: Melissa S Putman; Logan B Greenblatt; Michael Bruce; Taisha Joseph; Hang Lee; Gregory Sawicki; Ahmet Uluer; Leonard Sicilian; Isabel Neuringer; Catherine M Gordon; Mary L Bouxsein; Joel S Finkelstein Journal: J Clin Endocrinol Metab Date: 2021-03-08 Impact factor: 5.958