Literature DB >> 217337

Electrophoretic heterogeneity of 5-phosphoribosyl-1-pyrophosphate synthetase within and among humans.

R V Lebo, D W Martin.   

Abstract

The product of the enzyme 5-phosphoribosyl-1-pyrophosphate (PPriboseP) synthetase is a substrate for purine, pyrimidine, and pyridine biosynthesis and may be rate limiting for purine biosynthesis. A system developed to electrophoretically separate and histochemically detect PPriboseP synthetase in crude cell extracts has facilitated the identification of electrophoretically variant enzyme forms in the erythrocytes of five patients from a patient population of 200. Additional studies of human organs obtained at autopsy revealed a unique electrophoretic mobility for nearly each organ within the same individual.

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Year:  1978        PMID： 217337     DOI： 10.1007/bf00483742

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  24 in total

1.  [Course of glycolysis in mammal erythrocytes through 2,3-diphosphoglyceric acid; variant of glycolytic cycle at the level of phosphoglyceric acids].

Authors:  S RAPOPORT; C NIERADT
Journal:  Biochem Z       Date:  1955

2.  Overproduction of uric acid in primary gout.

Authors:  T F Yü; M E Balis; L C Yip
Journal:  Arthritis Rheum       Date:  1975 Nov-Dec

3.  X-linked pattern of inheritance of gout due to mutant feedback-resistant phosphoribosylpyrophosphate synthetase.

Authors:  E Zoref; A de Vries; O Sperling
Journal:  Adv Exp Med Biol       Date:  1977       Impact factor: 2.622

4.  Electrophoretic separation of normal and mutant phosphoribosylpyrophosphate synthetase.

Authors:  P Boer; O Sperling; A De Vries
Journal:  Adv Exp Med Biol       Date:  1974       Impact factor: 2.622

5.  Mutant phosphoribosylpyrophosphate synthetase in two gouty siblings with excessive purine production.

Authors:  O Sperling; S Persky-Brosh; P Boer; A De Vries
Journal:  Adv Exp Med Biol       Date:  1973       Impact factor: 2.622

6.  A specific enzyme defect in gout associated with overproduction of uric acid.

Authors:  W N Kelley; F M Rosenbloom; J F Henderson; J E Seegmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

7.  Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase.

Authors:  F M Rosenbloom; J F Henderson; I C Caldwell; W N Kelley; J E Seegmiller
Journal:  J Biol Chem       Date:  1968-03-25       Impact factor: 5.157

8.  Intracellular organic phosphates as regulators of oxygen release by haemoglobin.

Authors:  R Benesch; R E Benesch
Journal:  Nature       Date:  1969-02-15       Impact factor: 49.962

9.  An improved method for the electrophoretic separation and histochemical identification of 5-phosphoribosyl-1-pyrophosphate synthetase using microgram quantities of crude cell extracts.

Authors:  R V Lebo; D W Martin
Journal:  Adv Exp Med Biol       Date:  1977       Impact factor: 2.622

10.  The effect of ribose 5-phosphate and 5-phosphoribosyl-1-pyrophosphate availability on de novo synthesis of purine nucleotides in rat liver slices.

Authors:  P Boer; B Lipstein; A De Vries; O Sperling
Journal:  Biochim Biophys Acta       Date:  1976-04-15
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