Literature DB >> 21733685

Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin.

Shingo Kitada1, Shuji Fujita, Yohei Okada, Shokaku Kim, Kazuhiro Chiba.   

Abstract

Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21733685     DOI: 10.1016/j.bmcl.2011.06.004

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.

Authors:  Thimmalapura M Vishwanatha; Enrico Bergamaschi; Alexander Dömling
Journal:  Org Lett       Date:  2017-06-05       Impact factor: 6.005

2.  AJIPHASE®: A Highly Efficient Synthetic Method for One-Pot Peptide Elongation in the Solution Phase by an Fmoc Strategy.

Authors:  Daisuke Takahashi; Tatsuji Inomata; Tatsuya Fukui
Journal:  Angew Chem Int Ed Engl       Date:  2017-06-07       Impact factor: 15.336

  2 in total

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