BACKGROUND: UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidates for susceptibility genes, mainly in geographical regions exposed to high solar radiation. OBJECTIVE: Evaluate the role of host characteristics and DNA repair polymorphism in melanoma risk in Brazil. METHODS: We carried out a hospital-based case-control study in Brazil to evaluate the contribution of host factors and polymorphisms in DNA repair to melanoma risk. A total of 412 patients (202 with melanoma and 210 controls) were analyzed regarding host characteristics for melanoma risk as well as for 11 polymorphisms in DNA repair genes. RESULTS: We found an association of host characteristics with melanoma development, such as eye and hair color, fair skin, history of pigmented lesions removed, sunburns in childhood and adolescence, and also European ancestry. Regarding DNA repair gene polymorphisms, we found protection for the XPG 1104 His/His genotype (OR 0.32; 95% CI 0.13-0.75), and increased risk for three polymorphisms in the XPC gene (PAT+; IV-6A and 939Gln), which represent a haplotype for XPC. Melanoma risk was higher in individuals carrying the complete XPC haplotype than each individual polymorphism (OR 3.64; 95% CI 1.77-7.48). CONCLUSIONS: Our data indicate that the host factors European ancestry and XPC polymorphisms contributed to melanoma risk in a region exposed to high sun radiation.
BACKGROUND: UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidates for susceptibility genes, mainly in geographical regions exposed to high solar radiation. OBJECTIVE: Evaluate the role of host characteristics and DNA repair polymorphism in melanoma risk in Brazil. METHODS: We carried out a hospital-based case-control study in Brazil to evaluate the contribution of host factors and polymorphisms in DNA repair to melanoma risk. A total of 412 patients (202 with melanoma and 210 controls) were analyzed regarding host characteristics for melanoma risk as well as for 11 polymorphisms in DNA repair genes. RESULTS: We found an association of host characteristics with melanoma development, such as eye and hair color, fair skin, history of pigmented lesions removed, sunburns in childhood and adolescence, and also European ancestry. Regarding DNA repair gene polymorphisms, we found protection for the XPG 1104 His/His genotype (OR 0.32; 95% CI 0.13-0.75), and increased risk for three polymorphisms in the XPC gene (PAT+; IV-6A and 939Gln), which represent a haplotype for XPC. Melanoma risk was higher in individuals carrying the complete XPC haplotype than each individual polymorphism (OR 3.64; 95% CI 1.77-7.48). CONCLUSIONS: Our data indicate that the host factors European ancestry and XPC polymorphisms contributed to melanoma risk in a region exposed to high sun radiation.
Authors: Cristiane Oliveira; José Augusto Rinck-Junior; Gustavo Jacob Lourenço; Aparecida Machado Moraes; Carmen Silvia Passos Lima Journal: J Cancer Res Clin Oncol Date: 2013-04-09 Impact factor: 4.553
Authors: Fengju Song; Abrar A Qureshi; Jiangwen Zhang; Jiangwen Zhan; Christopher I Amos; Jeffrey E Lee; Qingyi Wei; Jiali Han Journal: DNA Repair (Amst) Date: 2012-01-09
Authors: Miguel Aracil; Lisa M Dauffenbach; Marta Martínez Diez; Rana Richeh; Victoria Moneo; Juan Fernando Martínez Leal; Luis Francisco García Fernández; Christopher A Kerfoot; Carlos M Galmarini Journal: Int J Clin Exp Pathol Date: 2013-01-15
Authors: Olinda C Luiz; Reinaldo José Gianini; Fernanda T Gonçalves; Guilherme Francisco; Cyro Festa-Neto; José Antonio Sanches; Gilka J F Gattas; Roger Chammas; José Eluf-Neto Journal: PLoS One Date: 2012-04-27 Impact factor: 3.240