| Literature DB >> 2173364 |
C Rivier1.
Abstract
We have shown that the endotoxin LPS acted both at the level of the brain and the gonads to stimulate the hypothalamic-pituitary-adrenal, and inhibit the hypothalamic-pituitary-gonadal, axis. Exogenously administered IL-1 mimics most of the effects of LPS on pituitary activity. In addition, antibodies against IL-1 receptors can interfere with LPS-induced ACTH secretion. These results suggest that at least part of the ability of LPS to alter endocrine functions appears to depend upon endogenous interleukin-1.Entities:
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Year: 1990 PMID： 2173364 DOI： 10.1007/978-1-4684-5799-5_18
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622