AIM: To evaluate the effect of regular aerobic exercise on the endothelial function and cardiorespiratory fitness in pregnant women. METHOD: This was a randomized, double-blinded, controlled clinical trial of 64 healthy primigravid women between 16 and 20 weeks' gestation. The experimental group took part in aerobic exercise at an intensity of 50-65% of their maximum heart rate for 60 min, three times a week for 16 weeks. The control group undertook their usual physical activity. The outcomes were the endothelial function evaluated by flow-mediated dilatation and cardiorespiratory fitness evaluated by the maximum indirect oxygen consumption (VO2max) in a 6-min walk test. RESULTS: Initially, no differences were found between the groups in any of the variables. At the end of the intervention, the participants that performed exercise showed a higher cardiorespiratory fitness, measured by the walked distance in the 6-min walk test (P = 0.014) and by the VO2max (P = 0.014). Also, the exercise group showed a lower heart rate at rest and a higher flow-mediated dilatation than the control group (P = 0.02). CONCLUSIONS:Regular aerobic exercise improves endothelium-dependent vasodilation in pregnancy. This intervention may be an early and effective alternative to strengthen the prevention of disorders associated to endothelial dysfunction.
RCT Entities:
AIM: To evaluate the effect of regular aerobic exercise on the endothelial function and cardiorespiratory fitness in pregnant women. METHOD: This was a randomized, double-blinded, controlled clinical trial of 64 healthy primigravid women between 16 and 20 weeks' gestation. The experimental group took part in aerobic exercise at an intensity of 50-65% of their maximum heart rate for 60 min, three times a week for 16 weeks. The control group undertook their usual physical activity. The outcomes were the endothelial function evaluated by flow-mediated dilatation and cardiorespiratory fitness evaluated by the maximum indirect oxygen consumption (VO2max) in a 6-min walk test. RESULTS: Initially, no differences were found between the groups in any of the variables. At the end of the intervention, the participants that performed exercise showed a higher cardiorespiratory fitness, measured by the walked distance in the 6-min walk test (P = 0.014) and by the VO2max (P = 0.014). Also, the exercise group showed a lower heart rate at rest and a higher flow-mediated dilatation than the control group (P = 0.02). CONCLUSIONS: Regular aerobic exercise improves endothelium-dependent vasodilation in pregnancy. This intervention may be an early and effective alternative to strengthen the prevention of disorders associated to endothelial dysfunction.
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