| Literature DB >> 21732038 |
Ryosuke Shirasaki1, Haruko Tashiro1, Yoko Oka1, Toshihiko Sugao1, Tadashi Yamamoto1, Mayumi Yoshimi1, Nobu Akiyama1, Kazuo Kawasugi1, Naoki Shirafuji2.
Abstract
The vascular endothelial growth factor (VEGF)-C system was analyzed in two cases of acute lymphocytic leukemia (ALL) with TCF3/PBX1 fusion to determine whether the VEGF-C system influences the growth of these ALL blasts. Bone marrow non-adherent mononuclear cells were prepared from the patients, and expressions of VEGFs and VEGF receptors (VEGFRs) were analyzed based on RNA and protein levels. Cell proliferation was also assayed with or without neutralizing antibodies to VEGFs. The patients' leukemic blasts expressed a significant amount of VEGF-C and VEGFR type-3. When anti-VEGF-C antibody was added to the blast cell cultures, cell proliferation was suppressed. These observations indicate that, in our ALL cases with TCF3/PBX1 fusion, VEGF-C autocrine stimulation plays an important role in the proliferation of ALL.Entities:
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Year: 2011 PMID： 21732038 DOI： 10.1007/s12185-011-0889-5
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490