Literature DB >> 21731595

PolyAna: analyzing synonymous and nonsynonymous polymorphic sites.

Ethan W Knapp1, Stephanie Jiménez Irausquin, Robert Friedman, Austin L Hughes.   

Abstract

PolyAna (available at http://www.biol.sc.edu/~austin/) aids in the analysis of natural selection on protein-coding sequences by estimating sample gene diversity at individual polymorphic nucleotide sites, which are classified as synonymous, non-synonymous, or ambiguous.

Entities:  

Year:  2011        PMID： 21731595      PMCID： PMC3124769          DOI： 10.1007/s12686-010-9372-5

Source DB:  PubMed          Journal:  Conserv Genet Resour            Impact factor:   0.973


  28 in total

Review 1.  Single nucleotide polymorphisms as tools in human genetics.

Authors:  I C Gray; D A Campbell; N K Spurr
Journal:  Hum Mol Genet       Date:  2000-10       Impact factor: 6.150

2.  SNPs in ecological and conservation studies: a test in the Scandinavian wolf population.

Authors:  J M Seddon; H G Parker; E A Ostrander; H Ellegren
Journal:  Mol Ecol       Date:  2005-02       Impact factor: 6.185

3.  Synonymous and nonsynonymous polymorphisms versus divergences in bacterial genomes.

Authors:  Austin L Hughes; Robert Friedman; Pierre Rivailler; Jeffrey O French
Journal:  Mol Biol Evol       Date:  2008-07-30       Impact factor: 16.240

4.  Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection.

Authors:  Steve Rozen; Janet D Marszalek; Raaji K Alagappan; Helen Skaletsky; David C Page
Journal:  Am J Hum Genet       Date:  2009-12       Impact factor: 11.025

5.  Widespread purifying selection at polymorphic sites in human protein-coding loci.

Authors:  Austin L Hughes; Bernice Packer; Robert Welch; Andrew W Bergen; Stephen J Chanock; Meredith Yeager
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-05       Impact factor: 11.205

6.  Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.

Authors:  Stephanie Jiménez Irausquin; Austin L Hughes
Journal:  Virus Res       Date:  2009-11-06       Impact factor: 3.303

7.  Low nucleotide diversity in man.

Authors:  W H Li; L A Sadler
Journal:  Genetics       Date:  1991-10       Impact factor: 4.562

8.  Relaxation of purifying selection on live attenuated vaccine strains of the family Paramyxoviridae.

Authors:  Austin L Hughes
Journal:  Vaccine       Date:  2009-02-03       Impact factor: 3.641

Review 9.  A comprehensive review of genetic association studies.

Authors:  Joel N Hirschhorn; Kirk Lohmueller; Edward Byrne; Kurt Hirschhorn
Journal:  Genet Med       Date:  2002 Mar-Apr       Impact factor: 8.822

Review 10.  Candidate genes and single nucleotide polymorphisms (SNPs) in the study of human disease.

Authors:  S Chanock
Journal:  Dis Markers       Date:  2001       Impact factor: 3.434
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  4 in total

1.  SNPGenie: estimating evolutionary parameters to detect natural selection using pooled next-generation sequencing data.

Authors:  Chase W Nelson; Louise H Moncla; Austin L Hughes
Journal:  Bioinformatics       Date:  2015-07-29       Impact factor: 6.937

2.  Accumulation of slightly deleterious mutations in the mitochondrial genome: a hallmark of animal domestication.

Authors:  Austin L Hughes
Journal:  Gene       Date:  2012-12-10       Impact factor: 3.688

Review 3.  Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.

Authors:  Chase W Nelson; Austin L Hughes
Journal:  Infect Genet Evol       Date:  2014-12-04       Impact factor: 3.342

4.  Subversion of Programed Cell Death by Poxviruses.

Authors:  Heather S Koehler; Bertram L Jacobs
Journal:  Curr Top Microbiol Immunol       Date:  2021-01-29       Impact factor: 4.737
  4 in total

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