BACKGROUND:Patients who undergo colorectal surgery have up to a 30% chance of developing a surgical site infection postoperatively. Silverlon is a silver nylon dressing designed to prevent surgical site infections, but only anecdotal evidence has previously supported its efficacy. OBJECTIVE: The aim of this study was to evaluate the effect of silver nylon dressings in patients undergoing colorectal surgery. DESIGN: We performed a prospective, randomized, controlled trial comparing a silver nylon dressing with gauze dressings in patients undergoing elective colorectal surgery. SETTING: The study was performed at a university-based, tertiary referral center. PATIENTS: We studied patients undergoing elective colorectal surgery with an abdominal skin incision of at least 3 cm. INTERVENTION: Patients were randomly assigned to receive either a silver nylon or a gauze dressing. MAIN OUTCOME MEASURES: The primary end point was surgical site infection occurring within 30 days of surgery. RESULTS:One hundred ten patients were enrolled in the study and were randomly assigned to 1 of 2 treatment groups. After a 30-day follow-up period, the incidence of surgical site infection was lower in the silver nylon group compared with the control group (13% vs 33%, P = .011). Twenty-five patients in the study developed superficial surgical site infections, 5 in the silver nylon group and 14 in the control group (P = .021). Two patients in the study group developed deep wound infections compared with 4 in the control group (P = .438). Multivariate analysis revealed that patients in the control group had a 3-fold increase in risk of infection compared with patients in the silver nylon group (P = .013). LIMITATIONS: A limitation of this study is that the members of the surgical team were not blinded to the treatment groups. CONCLUSION:Silver nylon is safe and effective in preventing surgical site infection following colorectal surgery.
RCT Entities:
BACKGROUND:Patients who undergo colorectal surgery have up to a 30% chance of developing a surgical site infection postoperatively. Silverlon is a silver nylon dressing designed to prevent surgical site infections, but only anecdotal evidence has previously supported its efficacy. OBJECTIVE: The aim of this study was to evaluate the effect of silver nylon dressings in patients undergoing colorectal surgery. DESIGN: We performed a prospective, randomized, controlled trial comparing a silver nylon dressing with gauze dressings in patients undergoing elective colorectal surgery. SETTING: The study was performed at a university-based, tertiary referral center. PATIENTS: We studied patients undergoing elective colorectal surgery with an abdominal skin incision of at least 3 cm. INTERVENTION: Patients were randomly assigned to receive either a silver nylon or a gauze dressing. MAIN OUTCOME MEASURES: The primary end point was surgical site infection occurring within 30 days of surgery. RESULTS: One hundred ten patients were enrolled in the study and were randomly assigned to 1 of 2 treatment groups. After a 30-day follow-up period, the incidence of surgical site infection was lower in the silver nylon group compared with the control group (13% vs 33%, P = .011). Twenty-five patients in the study developed superficial surgical site infections, 5 in the silver nylon group and 14 in the control group (P = .021). Two patients in the study group developed deep wound infections compared with 4 in the control group (P = .438). Multivariate analysis revealed that patients in the control group had a 3-fold increase in risk of infection compared with patients in the silver nylon group (P = .013). LIMITATIONS: A limitation of this study is that the members of the surgical team were not blinded to the treatment groups. CONCLUSION:Silver nylon is safe and effective in preventing surgical site infection following colorectal surgery.
Authors: Patrick C Sanger; Vlad V Simianu; Cameron E Gaskill; Cheryl A L Armstrong; Andrea L Hartzler; Ross J Lordon; William B Lober; Heather L Evans Journal: J Am Coll Surg Date: 2016-10-14 Impact factor: 6.113
Authors: Jo C Dumville; Trish A Gray; Catherine J Walter; Catherine A Sharp; Tamara Page; Rhiannon Macefield; Natalie Blencowe; Thomas Kg Milne; Barnaby C Reeves; Jane Blazeby Journal: Cochrane Database Syst Rev Date: 2016-12-20
Authors: Amani D Politano; Kristin T Campbell; Laura H Rosenberger; Robert G Sawyer Journal: Surg Infect (Larchmt) Date: 2013-02-28 Impact factor: 2.150
Authors: Patrick C Sanger; Gabrielle H van Ramshorst; Ezgi Mercan; Shuai Huang; Andrea L Hartzler; Cheryl A L Armstrong; Ross J Lordon; William B Lober; Heather L Evans Journal: J Am Coll Surg Date: 2016-05-14 Impact factor: 6.113
Authors: R L Nelson; N M Iqbal; A Kravets; R Khateeb; M Raza; M Siddiqui; I Taha; A Tummala; R Epple; S Huang; M Wen Journal: Tech Coloproctol Date: 2018-07-17 Impact factor: 3.781
Authors: Patrick C Sanger; Andrea Hartzler; Sarah M Han; Cheryl A L Armstrong; Mark R Stewart; Ross J Lordon; William B Lober; Heather L Evans Journal: PLoS One Date: 2014-12-01 Impact factor: 3.240