| Literature DB >> 2173013 |
E A Holwitt1, E Koda, C E Swenberg.
Abstract
The radioprotector WR-33278, the disulfide of WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane), is shown to stimulate eukaryotic topoisomerase I unwinding of negatively supercoiled DNA. This observation suggests the possibility that some protection may be conferred to DNA either by a decrease in its supercoiled state or by altering directly other enzymatic processes. This is the first report of a radioprotective compound stimulating an enzyme involved in DNA structure and synthesis.Entities:
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Year: 1990 PMID： 2173013
Source DB: PubMed Journal: Radiat Res ISSN： 0033-7587 Impact factor: 2.841