Jeong Han Kim1, Hyung Joon Yim2, Kwang Gyun Lee3, Seung Young Kim1, Eun Suk Jung4, Young Kul Jung4, Ji Hoon Kim4, Yeon Seok Seo3, Jong Eun Yeon4, Hong Sik Lee3, Soon Ho Um3, Kwan Soo Byun4, Ho Sang Ryu3. 1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-dong, Danwon-gu, Ansan-si, Gyeonggi-do, 425-707, Korea. 2. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-dong, Danwon-gu, Ansan-si, Gyeonggi-do, 425-707, Korea. gudwns21@medimail.co.kr. 3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Anam-dong, Seongbuk-gu, Seoul, 425-707, Korea. 4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Gurodong-gil, Guro-gu, Seoul, 425-707, Korea.
Abstract
PURPOSE: There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TACE for early stage HCC. METHODS: We reviewed the medical records of the patients who were diagnosed with early stage HCC between March 2006 and August 2008 at Korea University Medical Center and treated with RFA combined with TACE for curative intent (n = 65). RESULTS: Recurrence rate was 40% (26 cases) and the time to recurrence was 14.9 months. Cumulative recurrence rate at 1 year was 20% (13 cases) and at 2 years was 33.8% (22 cases). Significant variables for recurrence were: (1) RFA repeated more than one session at initial therapy (P < 0.001) and (2) size of main lesion ≥2 cm (P = 0.047). CONCLUSIONS: The recurrence rate of combination therapy was considerably high. Regardless of the therapy used, careful post-RFA follow-up is needed, especially if additional treatment is required after the first session or if the main lesion is ≥2 cm at the time of RFA.
PURPOSE: There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TACE for early stage HCC. METHODS: We reviewed the medical records of the patients who were diagnosed with early stage HCC between March 2006 and August 2008 at Korea University Medical Center and treated with RFA combined with TACE for curative intent (n = 65). RESULTS: Recurrence rate was 40% (26 cases) and the time to recurrence was 14.9 months. Cumulative recurrence rate at 1 year was 20% (13 cases) and at 2 years was 33.8% (22 cases). Significant variables for recurrence were: (1) RFA repeated more than one session at initial therapy (P < 0.001) and (2) size of main lesion ≥2 cm (P = 0.047). CONCLUSIONS: The recurrence rate of combination therapy was considerably high. Regardless of the therapy used, careful post-RFA follow-up is needed, especially if additional treatment is required after the first session or if the main lesion is ≥2 cm at the time of RFA.
Authors: Y Shiratori; S Shiina; M Imamura; N Kato; F Kanai; T Okudaira; T Teratani; G Tohgo; N Toda; M Ohashi Journal: Hepatology Date: 1995-10 Impact factor: 17.425
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Authors: Jason Chiang; Bridgett J Willey; Alejandro Muñoz Del Rio; J Louis Hinshaw; Fred T Lee; Christopher L Brace Journal: J Vasc Interv Radiol Date: 2014-09-23 Impact factor: 3.464