Literature DB >> 2172793

A functional retinoic acid receptor encoded by the gene on human chromosome 12.

T Ishikawa1, K Umesono, D J Mangelsdorf, H Aburatani, B Z Stanger, Y Shibasaki, M Imawari, R M Evans, F Takaku.   

Abstract

A cDNA clone derived from a human hepatocellular carcinoma has been isolated on the basis of homology to the alpha human retinoic acid receptor (RAR alpha) gene. Expression of this cDNA produces a high affinity nuclear binding protein for retinoic acid. The product of this clone when expressed in transfected cells is able to activate transcription of a reporter plasmid through specific DNA sequences in response to the addition of retinoic acid to the medium. Dose-dependent profiles upon trans-activation of the reporter indicate that apparent sensitivity to retinoic acid of this protein is approximately 10-fold higher than that of human RAR alpha and is comparable to that of the second human RAR, RAR beta. This gene has been mapped to human chromosome 12, which is distinct from those coding for either alpha or beta RAR, and thus encodes a third human RAR.

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Year:  1990        PMID： 2172793     DOI： 10.1210/mend-4-6-837

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  14 in total

1.  Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.

Authors:  J H Nadeau; J G Compton; V Giguère; J Rossant; S Varmuza
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

3.  Activation of mammalian retinoid X receptors by the insect growth regulator methoprene.

Authors:  M A Harmon; M F Boehm; R A Heyman; D J Mangelsdorf
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

4.  Ligand-dependent enhancement of human antithrombin gene expression by retinoid X receptor alpha and thyroid hormone receptor beta.

Authors:  R W Niessen; F Rezaee; P H Reitsma; M Peters; J J de Vijlder; A Sturk
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

5.  Tissue-specific distribution of a novel C-terminal truncation retinoic acid receptor mutant which acts as a negative repressor in a promoter- and cell-type-specific manner.

Authors:  T Matsui; S Sashihara
Journal:  Mol Cell Biol       Date:  1995-04       Impact factor: 4.272

6.  Physical mapping of the retinoid X receptor B gene in mouse and human.

Authors:  T Nagata; E H Weiss; K Abe; K Kitagawa; A Ando; Y Yara-Kikuti; M F Seldin; K Ozato; H Inoko; M Taketo
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

7.  Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.

Authors:  N A Morrison; R Yeoman; P J Kelly; J A Eisman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

8.  Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.

Authors:  K Damm; R A Heyman; K Umesono; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

9.  Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.

Authors:  P Ghazal; C DeMattei; E Giulietti; S A Kliewer; K Umesono; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

10.  Multiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cells.

Authors:  K A Robertson; B Emami; L Mueller; S J Collins
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272
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