Literature DB >> 2172791

Overexpression of phospholipase C-gamma in NIH 3T3 fibroblasts results in increased phosphatidylinositol hydrolysis in response to platelet-derived growth factor and basic fibroblast growth factor.

A Cuadrado1, C J Molloy.   

Abstract

Overexpression of phospholipase C-gamma in fibroblasts led to increased tyrosine phosphorylation of this enzyme in response to platelet-derived growth factor and basic fibroblast growth factor. This correlated with increased phosphoinositide release but not with enhanced mitogenicity. Thus, phospholipase C-gamma-mediated phosphoinositide metabolism may not be limiting in the signaling pathways initiated by these growth factors.

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Year:  1990        PMID： 2172791      PMCID： PMC361408          DOI： 10.1128/mcb.10.11.6069-6072.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  24 in total

Review 1.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

2.  Purification and characterization of a newly identified growth factor specific for epithelial cells.

Authors:  J S Rubin; H Osada; P W Finch; W G Taylor; S Rudikoff; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

Review 3.  Inositol trisphosphate and diacylglycerol: two interacting second messengers.

Authors:  M J Berridge
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

4.  Construction and applications of a highly transmissible murine retrovirus shuttle vector.

Authors:  C L Cepko; B E Roberts; R C Mulligan
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

5.  Tyrosine kinase-activating growth factors potentiate thrombin- and AIF4- -induced phosphoinositide breakdown in hamster fibroblasts. Evidence for positive cross-talk between the two mitogenic signaling pathways.

Authors:  S Paris; J C Chambard; J Pouysségur
Journal:  J Biol Chem       Date:  1988-09-15       Impact factor: 5.157

6.  Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

Authors:  P G Suh; S H Ryu; W C Choi; K Y Lee; S G Rhee
Journal:  J Biol Chem       Date:  1988-10-05       Impact factor: 5.157

7.  Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.

Authors:  M I Wahl; T O Daniel; G Carpenter
Journal:  Science       Date:  1988-08-19       Impact factor: 47.728

8.  Sequence similarity of phospholipase C with the non-catalytic region of src.

Authors:  M L Stahl; C R Ferenz; K L Kelleher; R W Kriz; J L Knopf
Journal:  Nature       Date:  1988-03-17       Impact factor: 49.962

9.  Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells.

Authors:  H Hasegawa-Sasaki
Journal:  Biochem J       Date:  1985-11-15       Impact factor: 3.857

10.  Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin.

Authors:  E Nånberg; E Rozengurt
Journal:  EMBO J       Date:  1988-09       Impact factor: 11.598
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  8 in total

1.  Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts.

Authors:  M Tomono; K Toyoshima; M Ito; H Amano
Journal:  Biochem J       Date:  1996-08-01       Impact factor: 3.857

2.  Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.

Authors:  C L Arteaga; M D Johnson; G Todderud; R J Coffey; G Carpenter; D L Page
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

3.  Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Authors:  K Hansen; M Johnell; A Siegbahn; C Rorsman; U Engström; C Wernstedt; C H Heldin; L Rönnstrand
Journal:  EMBO J       Date:  1996-10-01       Impact factor: 11.598

Review 4.  Growth factors and tyrosine protein kinases in normal and malignant melanocytes.

Authors:  R Halaban
Journal:  Cancer Metastasis Rev       Date:  1991-06       Impact factor: 9.264

5.  Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.

Authors:  A Kashishian; J A Cooper
Journal:  Mol Biol Cell       Date:  1993-01       Impact factor: 4.138

6.  NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.

Authors:  T Johansen; G Bjørkøy; A Overvatn; M T Diaz-Meco; T Traavik; J Moscat
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

Review 7.  Inhibitors of phosphatidylinositol signalling as antiproliferative agents.

Authors:  G Powis; D Phil
Journal:  Cancer Metastasis Rev       Date:  1994-03       Impact factor: 9.264

8.  Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.

Authors:  C J Molloy; T P Fleming; D P Bottaro; A Cuadrado; S A Aaronson
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272
  8 in total

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