BACKGROUND: Multidrug - resistant TB (MDR - TB) has emerged as a major threat to global TB control efforts in recent years. Facilities for its diagnosis and treatment are limited in many high - burden countries, including India. In hyper - endemic areas like Mumbai, screening for newly diagnosed cases at a higher risk of acquiring MDR - TB is necessary, for initiating appropriate and timely treatment, to prevent its further spread. OBJECTIVE: To assess risk factors associated with MDR - TB among Category I, new sputum smear-positive cases, at the onset of therapy. MATERIALS AND METHODS: The study applied an unmatched case - control design for 514 patients (106 cases with MDR - TB strains and 408 controls with non - MDR - TB strains). The patients were registered with the Revised National Tuberculosis Control Program (RNTCP) in four selected wards of Mumbai during April 2004 - January 2007. Data were collected through semi - structured interviews and drug susceptibility test results. RESULTS: Multivariate analysis indicated that infection with the Beijing strain (OR = 3.06; 95% C.I. = 1.12 - 8.38; P = 0.029) and female gender (OR = 1.68; 95% C.I. = 1.02 - 2.87; P = 0.042) were significant predictors of MDR-TB at the onset of therapy. CONCLUSION: The study provides a starting point to further examine the usefulness of these risk factors as screening tools in identifying individuals with MDR-TB, in settings where diagnostic and treatment facilities for MDR-TB are limited.
BACKGROUND: Multidrug - resistant TB (MDR - TB) has emerged as a major threat to global TB control efforts in recent years. Facilities for its diagnosis and treatment are limited in many high - burden countries, including India. In hyper - endemic areas like Mumbai, screening for newly diagnosed cases at a higher risk of acquiring MDR - TB is necessary, for initiating appropriate and timely treatment, to prevent its further spread. OBJECTIVE: To assess risk factors associated with MDR - TB among Category I, new sputum smear-positive cases, at the onset of therapy. MATERIALS AND METHODS: The study applied an unmatched case - control design for 514 patients (106 cases with MDR - TB strains and 408 controls with non - MDR - TB strains). The patients were registered with the Revised National Tuberculosis Control Program (RNTCP) in four selected wards of Mumbai during April 2004 - January 2007. Data were collected through semi - structured interviews and drug susceptibility test results. RESULTS: Multivariate analysis indicated that infection with the Beijing strain (OR = 3.06; 95% C.I. = 1.12 - 8.38; P = 0.029) and female gender (OR = 1.68; 95% C.I. = 1.02 - 2.87; P = 0.042) were significant predictors of MDR-TB at the onset of therapy. CONCLUSION: The study provides a starting point to further examine the usefulness of these risk factors as screening tools in identifying individuals with MDR-TB, in settings where diagnostic and treatment facilities for MDR-TB are limited.
Authors: M Ruddy; Y Balabanova; C Graham; I Fedorin; N Malomanova; E Elisarova; S Kuznetznov; G Gusarova; S Zakharova; A Melentyev; E Krukova; V Golishevskaya; V Erokhin; I Dorozhkova; F Drobniewski Journal: Thorax Date: 2005-02 Impact factor: 9.139
Authors: Karine Brudey; Jeffrey R Driscoll; Leen Rigouts; Wolfgang M Prodinger; Andrea Gori; Sahal A Al-Hajoj; Caroline Allix; Liselotte Aristimuño; Jyoti Arora; Viesturs Baumanis; Lothar Binder; Patricia Cafrune; Angel Cataldi; Soonfatt Cheong; Roland Diel; Christopher Ellermeier; Jason T Evans; Maryse Fauville-Dufaux; Séverine Ferdinand; Dario Garcia de Viedma; Carlo Garzelli; Lidia Gazzola; Harrison M Gomes; M Cristina Guttierez; Peter M Hawkey; Paul D van Helden; Gurujaj V Kadival; Barry N Kreiswirth; Kristin Kremer; Milan Kubin; Savita P Kulkarni; Benjamin Liens; Troels Lillebaek; Minh Ly Ho; Carlos Martin; Christian Martin; Igor Mokrousov; Olga Narvskaïa; Yun Fong Ngeow; Ludmilla Naumann; Stefan Niemann; Ida Parwati; Zeaur Rahim; Voahangy Rasolofo-Razanamparany; Tiana Rasolonavalona; M Lucia Rossetti; Sabine Rüsch-Gerdes; Anna Sajduda; Sofia Samper; Igor G Shemyakin; Urvashi B Singh; Akos Somoskovi; Robin A Skuce; Dick van Soolingen; Elisabeth M Streicher; Philip N Suffys; Enrico Tortoli; Tatjana Tracevska; Véronique Vincent; Tommie C Victor; Robin M Warren; Sook Fan Yap; Khadiza Zaman; Françoise Portaels; Nalin Rastogi; Christophe Sola Journal: BMC Microbiol Date: 2006-03-06 Impact factor: 3.605
Authors: Frank G J Cobelens; Einar Heldal; Michael E Kimerling; Carole D Mitnick; Laura J Podewils; Rajeswari Ramachandran; Hans L Rieder; Karin Weyer; Matteo Zignol Journal: PLoS Med Date: 2008-07-08 Impact factor: 11.069
Authors: Sachin R Atre; Jayshri D Jagtap; Mujtaba I Faqih; Yogita K Dumbare; Trupti U Sawant; Sunil L Ambike; Jitendra S Bhawalkar; Sandeep K Bharaswadkar; Padmaja K Jogewar; Ramji S Adkekar; Balasaheb P Hodgar; Vaishali Jadhav; Nitin D Mokashi; Jonathan E Golub; Avika Dixit; Maha R Farhat Journal: Am J Respir Crit Care Med Date: 2022-01-15 Impact factor: 21.405