In Kyoon Lyoo1, Jieun E Kim, Sujung J Yoon, Jaeuk Hwang, Sujin Bae, Dajung J Kim. 1. Department of Psychiatry and Interdisciplinary Program in Neuroscience, Seoul National University College of Medicine and College of Natural Sciences, 28 Yongon-dong, Jongno-gu, 110-744 Seoul, South Korea. inkylyoo@gmail.com
Abstract
CONTEXT: A multiwave longitudinal neuroimaging study in a cohort of direct survivors of a South Korean subway disaster, most of whom recovered from posttraumatic stress disorder 5 years after trauma, provided a unique opportunity to investigate the brain correlates of recovery from a severe psychological trauma. OBJECTIVES: To investigate region-specific brain mobilization during successful recovery from posttraumatic stress disorder by assessing cortical thickness multiple times from early after trauma to recovery, and to examine whether a brain-derived neurotrophic factor gene polymorphism was associated with this brain mobilization. DESIGN: Five-year follow-up case-control study conducted from 2003-2007. SETTING: Seoul National University and Hospital. PARTICIPANTS: Thirty psychologically traumatized disaster survivors and 36 age- and sex-matched control group members recruited from the disaster registry and local community, respectively, who contributed 156 high-resolution brain magnetic resonance images during 3 waves of assessments. MAIN OUTCOME MEASURES: Cerebral cortical thickness measured in high-resolution anatomic magnetic resonance images using a validated cortical thickness analysis tool and its prospective changes from early after trauma to recovery in trauma-exposed individuals and controls. RESULTS: Trauma-exposed individuals had greater dorsolateral prefrontal cortical (DLPFC) thickness 1.42 years after trauma (right DLPFC, 5.4%; left superior frontal cortex, 5.8%; and left inferior frontal cortex, 5.3% [all clusters, P ≤ .01]) relative to controls. Thicknesses gradually normalized over time during recovery. We found a positive linear trend, with trauma-exposed individuals with a valine/valine genotype having the greatest DLPFC cortical thickness, followed by those with a methionine genotype and controls (P < .001 for trend). Greater DLPFC thickness was associated with greater posttraumatic stress disorder symptom reductions and better recovery. CONCLUSION: The DLPFC region might play an important role in psychological recovery from a severely traumatic event in humans.
CONTEXT: A multiwave longitudinal neuroimaging study in a cohort of direct survivors of a South Korean subway disaster, most of whom recovered from posttraumatic stress disorder 5 years after trauma, provided a unique opportunity to investigate the brain correlates of recovery from a severe psychological trauma. OBJECTIVES: To investigate region-specific brain mobilization during successful recovery from posttraumatic stress disorder by assessing cortical thickness multiple times from early after trauma to recovery, and to examine whether a brain-derived neurotrophic factor gene polymorphism was associated with this brain mobilization. DESIGN: Five-year follow-up case-control study conducted from 2003-2007. SETTING: Seoul National University and Hospital. PARTICIPANTS: Thirty psychologically traumatized disaster survivors and 36 age- and sex-matched control group members recruited from the disaster registry and local community, respectively, who contributed 156 high-resolution brain magnetic resonance images during 3 waves of assessments. MAIN OUTCOME MEASURES: Cerebral cortical thickness measured in high-resolution anatomic magnetic resonance images using a validated cortical thickness analysis tool and its prospective changes from early after trauma to recovery in trauma-exposed individuals and controls. RESULTS:Trauma-exposed individuals had greater dorsolateral prefrontal cortical (DLPFC) thickness 1.42 years after trauma (right DLPFC, 5.4%; left superior frontal cortex, 5.8%; and left inferior frontal cortex, 5.3% [all clusters, P ≤ .01]) relative to controls. Thicknesses gradually normalized over time during recovery. We found a positive linear trend, with trauma-exposed individuals with a valine/valine genotype having the greatest DLPFC cortical thickness, followed by those with a methionine genotype and controls (P < .001 for trend). Greater DLPFC thickness was associated with greater posttraumatic stress disorder symptom reductions and better recovery. CONCLUSION: The DLPFC region might play an important role in psychological recovery from a severely traumatic event in humans.
Authors: Kristen M Wrocklage; Lynnette A Averill; J Cobb Scott; Christopher L Averill; Brian Schweinsburg; Marcia Trejo; Alicia Roy; Valerie Weisser; Christopher Kelly; Brenda Martini; Ilan Harpaz-Rotem; Steven M Southwick; John H Krystal; Chadi G Abdallah Journal: Eur Neuropsychopharmacol Date: 2017-03-06 Impact factor: 4.600
Authors: In Kyoon Lyoo; Sujung Yoon; Alan M Jacobson; Jaeuk Hwang; Gail Musen; Jieun E Kim; Donald C Simonson; Sujin Bae; Nicolas Bolo; Dajung J Kim; Katie Weinger; Junghyun H Lee; Christopher M Ryan; Perry F Renshaw Journal: Arch Gen Psychiatry Date: 2012-12
Authors: Gregory A Fonzo; Taru M Flagan; Sarah Sullivan; Carolyn B Allard; Erin M Grimes; Alan N Simmons; Martin P Paulus; Murray B Stein Journal: Psychiatry Res Date: 2012-11-13 Impact factor: 3.222
Authors: Filomene G Morrison; Mark W Miller; Erika J Wolf; Mark W Logue; Hannah Maniates; David Kwasnik; Jonathan D Cherry; Sarah Svirsky; Anthony Restaino; Audrey Hildebrandt; Nurgül Aytan; Thor D Stein; Victor E Alvarez; Ann C McKee; Bertrand R Huber Journal: Neurosci Lett Date: 2018-10-23 Impact factor: 3.046