BACKGROUND: Cognitive impairment is an established feature of schizophrenia. However, little is known about its relationship to the structural and functional brain abnormalities that characterise the disorder. Aims To identify structural and/or functional brain abnormalities associated with schizophrenic cognitive impairment. METHOD: We carried out structural magnetic resonance imaging (MRI) and voxel-based morphometry in 26 participants who were cognitively impaired and 23 who were cognitively preserved, all with schizophrenia, plus 39 matched controls. Nineteen of those who were cognitively impaired and 18 of those who were cognitively preserved plus 34 controls also underwent functional MRI during performance of a working memory task. RESULTS: No differences were found between the participants who were cognitively intact and those who were cognitively impaired in lateral ventricular volume or whole brain volume. Voxel-based morphometry also failed to reveal clusters of significant difference in grey and white matter volume between these two groups. However, during performance of the n-back task, the participants who were cognitively impaired showed hypoactivation compared with those who were cognitively intact in the dorsolateral prefrontal cortex among other brain regions. CONCLUSIONS: Cognitive impairment in schizophrenia is not a function of the structural brain abnormality that accompanies the disorder but has correlates in altered brain function.
BACKGROUND:Cognitive impairment is an established feature of schizophrenia. However, little is known about its relationship to the structural and functional brain abnormalities that characterise the disorder. Aims To identify structural and/or functional brain abnormalities associated with schizophrenic cognitive impairment. METHOD: We carried out structural magnetic resonance imaging (MRI) and voxel-based morphometry in 26 participants who were cognitively impaired and 23 who were cognitively preserved, all with schizophrenia, plus 39 matched controls. Nineteen of those who were cognitively impaired and 18 of those who were cognitively preserved plus 34 controls also underwent functional MRI during performance of a working memory task. RESULTS: No differences were found between the participants who were cognitively intact and those who were cognitively impaired in lateral ventricular volume or whole brain volume. Voxel-based morphometry also failed to reveal clusters of significant difference in grey and white matter volume between these two groups. However, during performance of the n-back task, the participants who were cognitively impaired showed hypoactivation compared with those who were cognitively intact in the dorsolateral prefrontal cortex among other brain regions. CONCLUSIONS:Cognitive impairment in schizophrenia is not a function of the structural brain abnormality that accompanies the disorder but has correlates in altered brain function.
Authors: Susan Whitfield-Gabrieli; Adina S Fischer; Angela M Henricks; Jibran Y Khokhar; Robert M Roth; Mary F Brunette; Alan I Green Journal: Schizophr Res Date: 2017-08-18 Impact factor: 4.939
Authors: Johanna Seitz-Holland; Joanne D Wojcik; Suheyla Cetin-Karayumak; Amanda E Lyall; Ofer Pasternak; Yogesh Rathi; Mark Vangel; Godfrey Pearlson; Carol Tamminga; John A Sweeney; Brett A Clementz; David A Schretlen; Petra Verena Viher; Katharina Stegmayer; Sebastian Walther; Jungsun Lee; Tim Crow; Anthony James; Aristotle Voineskos; Robert W Buchanan; Philip R Szeszko; Anil K Malhotra; Sinead Kelly; Martha E Shenton; Matcheri S Keshavan; Raquelle I Mesholam-Gately; Marek Kubicki Journal: Mol Psychiatry Date: 2022-08-18 Impact factor: 13.437
Authors: Silvia Alonso-Lana; José M Goikolea; Caterina M Bonnin; Salvador Sarró; Barbara Segura; Benedikt L Amann; Gemma C Monté; Noemi Moro; Paloma Fernandez-Corcuera; Teresa Maristany; Raymond Salvador; Eduard Vieta; Edith Pomarol-Clotet; Peter J McKenna Journal: PLoS One Date: 2016-07-22 Impact factor: 3.240