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Literature DB >> 21727136

Using stem cells to study and possibly treat type 1 diabetes.

Abstract

Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem cells are being used as reagents to test for drugs that slow or correct disease phenotypes found in several degenerative diseases. This paper explores these approaches in the context of type 1 or juvenile diabetes, pointing to recent successes as well as the technical and theoretical challenges that lie ahead in the path to new treatments and cures.

Entities: Disease

Mesh：

Year: 2011 PMID： 21727136 PMCID： PMC3130419 DOI： 10.1098/rstb.2011.0019

Source DB: PubMed Journal: Philos Trans R Soc Lond B Biol Sci ISSN： 0962-8436 Impact factor: 6.237

18 in total

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Authors: Yuval Dor; Juliana Brown; Olga I Martinez; Douglas A Melton
Journal: Nature Date: 2004-05-06 Impact factor: 49.962

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Journal: Nature Date: 2006-06-22 Impact factor: 49.962

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Journal: Physiol Rev Date: 2011-01 Impact factor: 37.312

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Journal: Am J Hum Genet Date: 1999-03 Impact factor: 11.025

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Journal: Nat Biotechnol Date: 2008-02-20 Impact factor: 54.908

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Authors: Richard I Sherwood; Tzong-Yang Albert Chen; Douglas A Melton
Journal: Dev Dyn Date: 2009-01 Impact factor: 3.780

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Authors: Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal: Cell Date: 2007-11-30 Impact factor: 41.582

9. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Authors: John A Todd; Neil M Walker; Jason D Cooper; Deborah J Smyth; Kate Downes; Vincent Plagnol; Rebecca Bailey; Sergey Nejentsev; Sarah F Field; Felicity Payne; Christopher E Lowe; Jeffrey S Szeszko; Jason P Hafler; Lauren Zeitels; Jennie H M Yang; Adrian Vella; Sarah Nutland; Helen E Stevens; Helen Schuilenburg; Gillian Coleman; Meeta Maisuria; William Meadows; Luc J Smink; Barry Healy; Oliver S Burren; Alex A C Lam; Nigel R Ovington; James Allen; Ellen Adlem; Hin-Tak Leung; Chris Wallace; Joanna M M Howson; Cristian Guja; Constantin Ionescu-Tîrgovişte; Matthew J Simmonds; Joanne M Heward; Stephen C L Gough; David B Dunger; Linda S Wicker; David G Clayton
Journal: Nat Genet Date: 2007-06-06 Impact factor: 38.330

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Authors: Qiao Zhou; Juliana Brown; Andrew Kanarek; Jayaraj Rajagopal; Douglas A Melton
Journal: Nature Date: 2008-08-27 Impact factor: 49.962

14 in total

1. Regulation of mesenchymal stem cell differentiation and insulin secretion by differential expression of Pdx-1.

Authors: Huijuan Yuan; Hongmei Liu; Rui Tian; Jie Li; Zhigang Zhao
Journal: Mol Biol Rep Date: 2012-04-10 Impact factor: 2.316

2. The evolving biology of cell reprogramming.

Authors: Ian Wilmut; Gareth Sullivan; Ian Chambers
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2011-08-12 Impact factor: 6.237

Review 3. Proteins and small molecules for cellular regenerative medicine.

Authors: Eric M Green; Richard T Lee
Journal: Physiol Rev Date: 2013-01 Impact factor: 37.312

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Authors: Ying Mei
Journal: Mater Today (Kidlington) Date: 2012-10-01 Impact factor: 31.041

5. Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes.

Authors: I K Manoylov; G V Boneva; I A Doytchinova; N M Mihaylova; A I Tchorbanov
Journal: Clin Exp Immunol Date: 2019-05-09 Impact factor: 4.330