| Literature DB >> 2172680 |
S Shibamoto1, T Hori, M Hayakawa, M Nango, E J Cragoe, N Oku, F Ito.
Abstract
The effects of three local anesthetics, lidocaine, dibucaine, and tetracaine, on Na+/H+ antiporter activity were examined in brush border membrane-reconstituted vesicles. Lidocaine at 10 microM inhibited H+ efflux in the presence of an inward Na+ gradient, suggesting that this anesthetic specifically inhibits the Na+/H+ antiporter. On the other hand, dibucaine and tetracaine decreased H+ efflux even in the absence of a Na+ gradient.Entities:
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Year: 1990 PMID： 2172680 DOI： 10.1016/0024-3205(90)90172-n
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037