Literature DB >> 21726660

Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease.

Adaliene Versiani Matos Ferreira1, Marcela Segatto, Zélia Menezes, Andréa Mara Macedo, Cláudio Gelape, Luciana de Oliveira Andrade, Fnu Nagajyothi, Philipp E Scherer, Mauro Martins Teixeira, Herbert B Tanowitz.   

Abstract

Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.
Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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Year:  2011        PMID： 21726660      PMCID： PMC3552247          DOI： 10.1016/j.micinf.2011.06.002

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  25 in total

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5.  Trypanosoma cruzi: possible stimulatory factor(s) on brown adipose tissue of mice.

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  49 in total

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Review 10.  Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease.

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